Gas Barrier Laminated Film and Process for Producing the Same

ABSTRACT

There are provided a gas barrier laminated film, which is transparent while possessing excellent gas barrier properties and, at the same time, has excellent impact resistance, and a process for producing the same. The gas barrier laminated film comprises a base material, a vapor deposited film of an inorganic oxide provided on the base material, and a gas barrier coating film provided on the vapor deposited film. The gas barrier laminated film is characterized in that the base material on its side where the vapor deposited film is provided, has been subjected to pretreatment or primer coating treatment, and the gas barrier coating film has been formed by coating a gas barrier coating liquid onto the inorganic oxide film and then heating the coating.

This application claims the benefit of U.S. Provisional Application No. 60/566,496, filed Apr. 29, 2004.

FIELD OF THE INVENTION

The present invention relates to diazole and triazole derivatives and compositions containing the same, which are useful for controlling insects and acarids in agricultural crops. More particularly, this invention relates to certain multiply substituted diazole and triazole derivatives, compositions containing them, and their use as insecticides against insects, such as cotton aphid.

BACKGROUND OF THE INVENTION

There is a continuing demand for new insecticides and acaricides that are safer, more effective, and less costly. Insecticides and acaricides are useful for controlling insects and acarids which may otherwise cause significant damage to crops such as wheat, corn, soybeans, potatoes, and cotton to name a few. For crop protection, insecticides and acaricides are desired which can control the insects and acarids without damaging the crops, and have no deleterious effects to mammals and other living organisms.

A number of patents and publications disclose a variety of substituted benzimidazoles, some of which have insecticidal and acaricidal activity.

For example, as set forth in German Offenlegungsschrift DE 42 37 567 A1, certain 1-substituted 2-cyanobenzimidazole derivatives of the following formula are useful as insecticides, acaricides, nematicides, and fungicides:

where,

-   X₁-X₄ are hydrogen; halogen; cyano; nitro; optionally substituted     alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, or     cycloalkyl; optionally substituted fused alkylenedioxy; COOH;     alkanoyl; alkoxycarbonyl; cycloalkoxycarbonyl; optionally     substituted amino or carbamoyl; or Ar₁; OAr₁; SAr₁; SOAr₁, SO₂Ar₁;     OSO₂Ar₁, COAr₁, COOAr₁, N═NAr₁; or SO₂CH₂SAr₁; at least one being     other than hydrogen and halogen; -   Ar₁ is optionally substituted aryl; -   R₁ is hydrogen; alkyl; or optionally substituted aryl; -   R₂ is hydroxy; cyano; optionally substituted alkyl, alkenyl,     alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, amino, alkanoyl,     alkoxycarbonyl, alkanoyloxy, or dialkoxyphosphoryl; or Ar₂; COAr₂;     COOAr₂; OCOAr₂; or OCONHCONHAr₂; -   Ar₂ is optionally substituted aryl or heteroaryl.

As set forth in Belgian Patent BE 829,630, certain 1-hydroxy-2,6-bis(polyfluoroalkyl)-4-nitrobenzimidazole ethers and esters of the following formula are useful as herbicides, insecticides, and as intermediates for other benzimidazoles:

where,

-   R₁ is hydrogen; chlorine; fluorine; 1-6C perfluoroalkyl; or     —(CHZ)_(n)CH₂Z, where each Z is hydrogen or halogen, n is 0-1; -   R₂ is CF₃; CF₂Cl; or CF₂H; -   R₃ is 1-8C alkyl; 2-8C alkenyl; 5-6C cycloalkyl; benzyl; phenethyl;     2-16C alkanoyl; 3-16C alkenoyl; CXNR₄R₄ (X is O, or S; R₄ is 1-4C     alkyl, or 2-4C alkenyl, and one of them may also be hydrogen; the     two R₄'s together are not more than 5C, or the two R₄'s can together     be 2-6C alkylene); CO(R₅)_(n)Ph (R₅ is CH₂, CH₂CH₂, or CH═CH); COQ,     or COR₆OQ (Q is phenyl substituted with 1-3 same or different NH₂,     NO₂, F, CH₃, or OCH₃; R₆ is 1-4C alkylene); SO₂R₇ (R₇ is 1-4C alkyl,     5-6C cycloalkyl, phenyl optionally substituted as above, or benzyl);     2-tetrahydrofuranyl, COXPh, or COX(1-4 alkyl).

As set forth in Belgian Patent BE 766,870, certain benzimidazole derivatives of the following formula are acaricidal:

where;

-   X is hydrogen, halogen, NO₂, CF₃, CH₃SO₂, C₂H₅SO₂, CN; -   n is 1-4; -   R₁ is hydrogen; (Ph)₃C, (p-Cl-Ph)₃C, COOR₆ (R₆ is 1-8C alkyl, or     phenyl), when R₂ is CF₂CHCl₂ or (b) R1 is OH, OR₃ (R₃ is 1-8C alkyl;     2,4-dinitrophenyl), OC(═O)OR₄ (R₄ is 1-8C alkyl, or phenyl),     OC(═O)R₅ (R₅ is 1-10C alkyl or alkenyl, or phenyl) when R₂ is     CF₂CHCl₂, CF₂C₁, CF₂OCH₃, CCl═CCl₂, CF₃ provided that R₂ is not OH     when R₂ is CF₃ or CF₂CFCl₂, or (c) R₁ is hydrogen or Rhal when R₂ is     S-Rhal provided that Rhal is identical for R₁ and R₂ and is     CF₂CHClF, CF₂CHF₂, CF₂CHFCF₃, CF₂CH₂C₁, CF₂CH₂Br, and CF₂CHCl₂.

In some instances benzimidazole derivatives have also found utility for control of insects and acarids that prey on animals found in the animal husbandry industry.

For example, as set forth in U.S. Pat. No. 3,980,784, certain benzimidazoles of the following formula are useful in the control of insect and acarid animal parasites:

where

-   R is C₁, CF₃, CHF₂, CCl₂F; -   R¹ is hydrogen, OH, CO₂R⁴, C(═O)R⁵, SO²R⁵, C(═S)N(C₁-C₃alkyl)₂,     O(C₁-C₃alkyl), or OC(═O)R⁵; -   R² is CClF₂, CF₂CHF₂, CF₂CF₃, CF2CF₂CF₃, or CF(CF₃)₂; -   R³ is C₁-C₆alkyl, C₂-C₃alkenyl, phenyl, or benzyl; -   R⁴ is C₁-C₅alkyl, phenyl, chlorophenyl, anisyl, or tolyl; -   R⁵ is C₁-C₃alkyl, or phenyl; -   or the ammonium, alkali metal, or alkaline earth metal salts of the     above compounds wherein R¹ is hydrogen.

Among the different categories of insect pests preying on agricultural crops are, for example, the piercing-sucking insects that remove plant carbohydrates and nutrients. This type of insect may also inject toxins while feeding that add to the injury of the crop plant. Examples of the piercing-sucking insects include, without limitation, lygus bugs, aphids, whiteflies, plant hoppers, and other piercing-sucking insects. It is estimated that the piercing-sucking insects alone cause in excess of two billion dollars worth of damage to agricultural crops worldwide each year. Accordingly, control of piercing-sucking insects, as well as other categories of insects, that negatively impact agricultural crops is needed.

SUMMARY OF THE INVENTION

In accordance with the present invention, it has been found that certain defined diazole and triazole derivatives, more particularly multiply substituted diazole and triazole derivatives, and agriculturally acceptable salts and metal complexes thereof, are useful as active ingredients in the insecticidal compositions and methods of this invention. These diazole and triazole derivatives are represented by the following general formula (I)

where M, Q, R, R¹, R², W, X, Y, and R⁴ are described below. Among the preferred compounds are those where Q is carbon; R is hydrogen, halogen, or straight or branched chain alkyl; R¹ and R² taken together are —CH═CHCH═CH—, —C(Cl)═CHCH═CH—, —C(F)═CHCH═CH—, or —C(CH₃)═CHCH═CH—; X is straight or branched chain alkylenyl or —(CH₂)_(m)—U(R⁵)_(p)—(CH₂)_(m) ₁ —, where U is carbon; Y is phenyl, benzo[b]furanyl, benzodioxolanyl, or oxaindanyl where Y is substituted with R⁴, which is one or more of hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, amino, or —(O)_(t)—(CH₂)_(v)-Z-R⁶, where Z is —C(R⁷)═C(R⁸)—, —C≡C—, or —C(R⁷)═NO—; and m, p, m¹, t, v, R⁵, R⁶, R⁷, and R⁸ are described below.

The present invention is also directed to compositions containing an insecticidally effective amount of at least one of a compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier.

The present invention is also directed to methods of controlling insects, where control is desired, which comprise applying an insecticidally effective amount of the above composition to the locus of crops, or other areas where insects are present or are expected to be present.

DETAILED DESCRIPTION OF THE INVENTION

One aspect of the present invention relates to certain new and useful compounds, namely certain novel multiply substituted diazole and triazole derivatives that possess unexpected insecticidal activity. These diazole and triazole derivatives are represented by the following general formula (I)

wherein;

-   M is carbon or nitrogen; -   Q is selected from the group consisting of carbon, nitrogen, and     carbonyl; -   when Q is carbonyl,     -   the nitrogen in the 3-position is optionally substituted with         alkyl; and -   when Q is carbon, -   R is selected from the group consisting of hydrogen, halogen,     hydroxy, thiol, straight or branched chain alkyl, cycloalkyl,     alkoxy, alkenyl, alkenyloxy haloalkyl, hydroxyalkyl, alkylthio,     alkoxyalkyl, carboxyl, formyl, aminocarbonyl, amino, cyano, nitro,     alkylsulfonyl, aminosulfonyl, cyanoalkyl, cyanothio, cyanothioalkyl,     alkylcarbonyl haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl,     alkoxycarbonylalkylthio, and aminocarbonylalkyl, where the amino     group may be substituted with one or two substituents independently     selected from alkyl, hydroxy, alkoxy, carboxyl, aryl, alkylcarbonyl,     haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl,     alkylsulfonyl, and haloalkylsulfonyl; -   R¹ and R² are independently selected from the group consisting of     hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio,     haloalkylthio, haloalkylsulfinyl, haloalkylsulfonyl, amino,     alkylamino, dialkylamino, aryl, and heteroaryl, where aryl and     heteroaryl are optionally substituted with one or more of halogen,     alkyl, haloalkyl, alkoxy, and haloalkoxy; and, -   R¹ and R² taken together are C₃-C₅ alkylenyl, —CH₂CH₂O—,     —CH₂CH₂C(CH₃)₂O—, —OCH₂O—, —OCH₂CH₂O—, —OCF₂CF₂—, —CF₂CF₂O—,     —OCF₂CF₂O—, —CH═CHCH═CH—, —CH═CHO—, —CH═CHN—, —CH═C(Br)N—,     —CH═C(CF₃)N—, —CH═C(CN)N—, —CH═C(NO₂)N—, —CH═CHS—, —CH═C(CH₂OCH₃)O—,     —CH═C(CH₃)S—, —CH═C(CF₃)S—, —CH═NN(CH₃)—, —CH═NN(C₂H₅)—,     —C(CH₃)═NN(CH₃)—, —N═CHNH—, —C(Cl)═CHCH═CH—, —CH═C(Br)CH═CH—,     —C(F)═CHCH═CH—, —C(CH₃)═CHCH═CH—, —CH═C(CH₃)CH═CH—,     —CH═CHC(CH₃)═CH—, —CH═C(CH₃)C(CH₃)═CH—, —C(CH₃)═CHCH═C(CH₃)—,     —C(OCH₃)═CHCH═CH—, —C(C≡CH)═CHCHC═CH—, —CH═CHC(Cl)═CH—,     —CH═C(NO₂)CH═N—, —OCH═CH—, —CH═C(CF₃)CH═N—, —CH═CHCH═C(Cl)—,     —C(CF₃)═CHCH═CH—, —SCH═CH—, —C(Cl)═NCH═CH—, —CH₂SCH₂—, —CH₂S(O)CH₂—,     —CH₂S(O)₂CH₂—, —SN═N—, —CH₂N(C₂H₅)CH₂—, ═CHN(C₂H₅)CH═,     —N(CH₃)CH═CH—, —N(CH₂Ph)CH═CH—, —N═CHS—, —N═C(CH₃)S—, —N═CHCH═CH—,     —CH═CHN═CH—, —CH═NCH═CH—, —CH═CHC(NO₂)═CH—, —CH═CHCH═N—,     —N═CHC(CF₃)═CH—, —CH═C(F)CH═CH—, —C(F)═C(F)CH═CH—, —CH═CHC(F)═CH—,     —CH═C(F)C(F)═CH—, —CH═CHCH═C(F)—, —CH═CHCH═C(CH₃)—,     —C(CH₃)═C(CH₃)CH═CH—, —C(CH₃)═CHC(CH₃)═CH—, and —C(CN)═CHCH═CH—; -   W is selected from the group consisting of oxygen, —C₆H₄—, —CH₂—,     NR³, N═, sulfur, S(O), and S(O)₂, where R³ is hydrogen, alkyl,     haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylcarbonyl,     haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl,     alkylsulfonyl, haloalkylsulfonyl, and aryl; -   X is selected from the group consisting of straight or branched     chain alkylenyl, alkylenyloxy, alkenylenyl, alkynylenyl; and     —(CH₂)_(m)—U(R⁵)_(p)—(CH₂)_(m) ₁ —, where m and m¹ are independently     0-4; U is carbon, CH, Si, S(O)_(r), N(═O)_(q), or C═O, where r is     0-2, and q is 0 or 1; and when U is carbon, R⁵ is C₂-C₅ alkylenyl,     and p is 1; when U is CH, R⁵ is hydroxy, or alkoxy, and p is 1; when     U is S¹, R⁵ is alkyl, and p is 1-2; when U is S(O)_(r), p is 0; when     U is N(═O)_(q), R⁵ is alkyl, and p is 1; and when U is C═O, p is 0; -   Y is selected from the group consisting of cycloalkyl, phenyl,     benzo[b]furanyl, benzodioxolanyl, pyridyl, pyrimidinyl, pyridazinyl,     thienyl, 1,3-thiazolyl, 1,3,4-thiadiazolyl, furanyl, 1,3-oxazolyl,     1,3,4-oxadiazolyl, pyrrolyl, 1-methylpyrrolyl, pyrazolyl,     benzoxazolyl, 1-methylpyrazolyl, imidazolyl, 2H-tetrazolyl,     1-methyl-2H-1,3-diazolyl, 4H-1,4-benzoxazinyl,     4H-1,4-benzoxazin-3-onyl, adamantyl, naphthyl, oxaindanyl,     benzo[b]-1,3-dioxolanyl, and a bond bridging X and R⁴; and Y is     optionally substituted with one or more of R⁴, where -   R⁴ is selected from the group consisting of hydrogen, halogen,     alkyl, haloalkyl, alkoxyalkyl, hydroxy, alkoxy, haloalkoxy,     hydroxyalkoxy, alkoxyalkoxy, alkoxyalkoxyalkoxy, cycloalkoxy,     cycloalkylalkoxy, cycloalkoxyalkyl, alkylthio, alkylsulfinyl,     alkylsulfonyl, cyano, cyanoalkoxy, nitro, amino, alkylamino,     dialkylamino, alkylaminoalkoxy, guanadinoalkoxy, alkylsulfonylamino,     carboxyl, alkylcarbonyl, alkoxycarbonyl, dialkylphosphonyl,     trialkylsilylalkoxy, aryl, aryloxy, arylalkoxy, aryloxyalkoxy,     arylsulfonylalkoxy, arylalkyliminoalkoxy, arylcarbonylaminoalkoxy,     heteroaryl, heteroaryloxy, heteroarylalkoxy,     2,4-dialkyl-1,3-dioxolanyl, 1,2,3-trihydro-2-azaquinazolin-4-onyl,     and —(O)_(t)—(CH₂)_(v)-Z-R⁶ where t is 0 or 1, v is 0-4; Z is     —C(R⁷)═C(R⁸)—, —OCH₂C(R⁷)═C(R⁸)—, —C≡C—, —C≡CS—, —C≡CN(R⁷)—,     —C≡CCO₂—, and —C(R⁷)═NO—, and where the aryl of aryl, aryloxy,     arylalkoxy, aryloxyalkoxy, arylsulfonylalkoxy, arylalkyliminoalkoxy,     arylcarbonylaminoalkoxy, heteroaryl, heteroaryloxy, and     heteroarylalkoxy is optionally substituted with one or more of     halogen, alkyl, haloalkyl, alkoxy, and haloalkoxy; -   R⁶ is selected from the group consisting of hydrogen, halogen,     alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, haloalkyl,     alkylthioalkyl, trialkylsilyl, aminoalkyl, alkylaminoalkyl,     dialkylaminoalkyl, alkylcarbonyl, alkylcarbonyl,     alkoxycarbonylalkyl, alkoxycarbonylalkyl, aryl, arylalkyl,     heteroaryl, and heteroarylalkyl; -   R⁷ and R⁸ are independently selected from the group consisting of     hydrogen, halogen, alkyl, and haloalkyl, and R⁷ and R⁸ taken     together are C₂-C₅ alkylenyl; and agriculturally-acceptable salts     and agriculturally acceptable metal complexes thereof.

Preferred species are those compounds of formula (I) where M and Q are carbon; R is hydrogen, halogen, hydroxy, straight or branched chain alkyl, or amino; R¹ and R² taken together are —CH═CHCH═CH—, —C(Cl)═CHCH═CH—, —C(F)═CHCH═CH—, —CH═C(F)CH═CH—, —CH═CHC(F)═CH—, —CH═CHCH═C(F)—, —C(F)═C(F)CH═CH—, —CH═C(F)C(F)═CH—, —C(CH₃)═CHCH═CH—, —CH═C(CH₃)CH═CH—, —C(OCH₃)═CHCH═CH—, —C(C≡CH)═CHCHC═CH—, —C(CF₃)═CHCH═CH—, —N═CHCH═CH—, —CH═NCH═CH—, or —CH═CHCH═N—; W is oxygen, or NR³, where R³ is hydrogen; X is straight or branched chain alkylenyl or —(CH₂)_(m)—U(R⁵)_(p)—(CH₂)_(m) ₁ —, where U is carbon, CH, or C═O; Y is cycloalkyl, phenyl, benzo[b]furanyl, benzodioxolanyl, pyridyl, naphthyl, or oxaindanyl, R⁴ is one or more of hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkoxy, cycloalkoxy, cycloalkylalkoxy, cyano, amino, alkylamino, dialkylamino, alkoxycarbonyl, aryl, heteroaryl, 2,4-dialkyl-1,3-dioxolanyl, or —(O)_(t)—(CH₂)_(v)-Z-R⁶ where Z is —C(R⁷)═C(R⁸)—, —OCH₂C(R⁷)═C(R⁸)—, —C_C—, or —C(R⁷)═NO—; R⁶ is hydrogen, halogen, alkyl, or haloalkyl; and R⁷ and R⁸ are independently hydrogen, halogen, or alkyl.

More preferred are those compounds of formula (I) where Q is carbon; R is hydrogen, halogen, or straight or branched chain alkyl; R¹ and R² taken together are —CH═CHCH═CH—, —C(Cl)═CHCH═CH—, —C(F)═CHCH═CH—, or —C(CH₃)═CHCH═CH—;

X is straight or branched chain alkylenyl or —(CH₂)_(m)—U(R⁵)_(p)—(CH₂)_(m) ₁ —, where U is carbon; Y is phenyl, benzo[b]furanyl, benzodioxolanyl, or oxaindanyl; R⁴ is one or more of hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, amino, or —(O)_(t)—(CH₂)_(v)-Z-R⁶, where Z is —C(R⁷)═C(R⁸)—, —C≡C—, or —C(R⁷)═NO—; and, R⁶ is hydrogen, halogen, or alkyl.

Yet more preferred are those compounds of formula (I) where R is methyl; X is ethylenyl; Y is phenyl; R⁴ is one or more of hydrogen, halogen, alkyl, alkoxy, haloalkoxy, cyano, amino, or —(O), —(CH₂)_(v)-Z-R⁶, Z is —C(R⁷)═NO—; R⁶ is alkyl; and R⁷ is hydrogen.

Most preferred are those compounds of formula (I) where R⁴ is i) 3-chloro-4-butoxy; ii) 3-fluoro-4-butoxy; iii) 3-methyl-4-butoxy; iv) 3-cyano-4-butoxy; v) 3,5-dichloro-4-butoxy; vi) 3,5-dimethyl-4-butoxy; vii) 3-amino-5-chloro-4-butoxy; viii) 3-chloro-4-(4-fluorobutoxy); and ix) 4-(O)_(t)—(CH₂)_(v)-Z-R⁶, where t and v are 0; and R⁶ is ethyl.

In addition, in certain cases the compounds of formula (I) possess asymmetric centers, which can give rise to optical enantiomorphs and diastereomers. The compounds may also possess acidic or basic moieties, which may allow for the formation of agriculturally acceptable salts or agriculturally acceptable metal complexes. This invention includes such enantiomorphs, salts and metal complexes. Agriculturally acceptable salts and metal complexes include, without limitation, for example, ammonium salts, the salts of hydrochloric acid, sulfonic acid, ethanesulfonic acid, trifluoroacetic acid, methylbenzenesulfonic acid, phosphoric acid, gluconic acid, pamoic acid, and other acid salts, and the alkali metal and alkaline earth metal complexes with, for example, sodium, potassium, lithium, magnesium, calcium, and other metals.

Another aspect of the present invention relates to compositions containing an insecticidally effective amount of at least one compound of formula (I) with at least one insecticidally compatible carrier therefor.

Another aspect of the present invention relates to compositions containing an insecticidally effective amount of at least one compound of formula (I), and an effective amount of at least one second compound, with at least one insecticidally compatible carrier therefor.

Another aspect of the present invention relates to methods of controlling insects by applying an insecticidally effective amount of a composition set forth above to a locus of crops such as, without limitation, cotton, vegetables, and fruits, or other areas where insects are present or are expected to be present.

The modifier “about” is used herein to indicate that certain preferred operating ranges, such as ranges for molar ratios for reactants, material amounts, and temperature, are not fixedly determined. The meaning will often be apparent to one of ordinary skill. For example, a recitation of a temperature range of about 120° C. to about 135° C. in reference to, for example, an organic chemical reaction would be interpreted to include other like temperatures that can be expected to favor a useful reaction rate for the reaction, such as 105° C. or 150° C. Where guidance from the experience of those of ordinary skill is lacking, guidance from the context is lacking, and where a more specific rule is not recited below, the “about” range shall be not more than 10% of the absolute value of an end point or 10% of the range recited, whichever is less.

As used in this specification and unless otherwise indicated the substituent terms alkyl, alkoxy, alkanoate, alkanoic, and haloalkyl, used alone or as part of a larger moiety, includes straight or branched chains of at least one or two carbon atoms, as appropriate to the substituent, and preferably up to 12 carbon atoms, more preferably up to ten carbon atoms, most preferably up to seven carbon atoms. The term “cycloalkyl”, used alone or as part of a larger moiety, includes rings of three to twelve carbon atoms, preferably three to six carbon atoms. The term “alkenyl”, used alone or as part of a larger moiety, includes straight or branched chains of at least two carbon atoms containing at least one carbon-carbon double bond, and preferably up to 12 carbon atoms, more preferably up to ten carbon atoms, most preferably up to seven carbon atoms. The term “aryl” refers to an aromatic ring structure, including fused rings, having four to ten carbon atoms. The term “heteroaryl” refers to an aromatic ring structure, including fused rings, having at least one nitrogen, sulfur, or oxygen atom. The term “THF” refers to tetrahydrofuran. The term “DMF” refers to N,N-dimethylformamide, The term “DEAD” refers to diethyl azodicarboxylate. “Halogen” or “halo” refers to fluorine, bromine, iodine, or chlorine.

The diazole and triazole derivatives of formula (I) can be synthesized by methods that are individually known to one skilled in the art from intermediate compounds readily available in commerce. Scheme I below illustrates a general procedure for synthesizing diazole and triazole derivatives of formula (I), inter alia, where W is amino (NR³ where R³ is hydrogen) or oxygen, X is ethylenyl, and Y is phenyl:

Intermediate (1), for example, a 1-hydroxydiazole or a 1-hydroxytriazole, can be reacted (Reaction C) with an appropriately substituted alkyl halide (3), under basic conditions in a suitable solvent, for example, DMF and acetone, affording compounds of formula (I) where W is oxygen.

In a preferred method, Intermediate (1) can be reacted (Reaction B) with triphenylphosphine, DEAD, and an appropriately substituted alkyl alcohol (3), in a suitable solvent, for example, THF, also affording compounds of formula (I) where W is oxygen. Examples of 1-hydroxydiazoles or 1-hydroxytriazoles useful in the context of the present invention include, without limitation, 1-hydroxy-2-methylbenzimidazole, 4-chloro-1-hydroxy-2-methylbenzimidazole, 4-fluoro-1-hydroxy-2-methylbenzimidazole, 1-hydroxy-2,4-dimethylbenzimidazole, 1-hydroxy-2-methyl-4,5,6,7-tetrahydrobenzimidazole, 1-hydroxy-2,4,5-trimethylimidazole, 1-hydroxy-1H-benzotriazole hydrate, and other 1-hydroxydiazoles and 1-hydroxytriazoles (1). Examples of substituted alkyl halides and substituted alkyl alcohols (3) useful in the context of the present invention include, without limitation, 2-(3-chloro-4-n-butoxyphenyl)ethanol, 2-[3-chloro-4-(1,1-dimethylethyl)phenyl]ethyl bromide, 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethanol, and other substituted alkyl halides (3) and substituted alkyl alcohols (3). Detailed Examples of Reactions B and C are set forth as Examples 1, 2, 4, 6, 9, 11-13, and 16 hereinbelow.

Intermediate (2), for example, a 1-aminodiazole or a 1-aminotriazole, can be reacted (Reaction D) with an appropriately substituted alkyl aldehyde (4) and a suitable reducing agent, for example, sodium borohydride or sodium cyanoborohydride, in a suitable solvent, for example, ethanol or acetic acid, affording compounds of formula (I) where W is amino. Examples of 1-aminodiazoles or 1-aminotriazoles useful in the context of the present invention include, without limitation, 1-amino-2-methylbenzimidazole, 1-amino-4-chloro-2-methylbenzimidazole, 1-amino-4-fluoro-2-methylbenzimidazole, 1-amino-5-fluoro-2-methylbenzimidazole, 1-amino-2,4-dimethylbenzimidazole, 1-amino-1,3-dihydro-3-methyl-2H-benzimidazol-2-one, and other 1-aminodiazoles or 1-aminotriazoles (2). Examples of substituted alkyl aldehydes (4) useful in the context of the present invention include, without limitation, 3-chloro-4-n-butoxyphenylacetaldehyde, 4-n-butoxy-3,5-dimethylbenzaldehyde, propyl 2-chloro-4-formylmethylbenzoate, 2-methyl-2-(4-n-butoxyphenyl)propionaldehyde, and other substituted alkyl aldehydes (4). Detailed Examples of Reaction D are set forth as Examples 3, 5, 7, 8, 10, 14 and 15 hereinbelow.

Intermediates (1) and (2), useful in the preparation of compounds of formula (I) are available in commerce or can be prepared using methods known to one skilled in the art.

Intermediates (1), for example, 4-fluoro-1-hydroxy-2-methylbenzimidazole and 1-hydroxy-2,4-dimethylbenzimidazole, were prepared in a step-wise manner by first aminating the corresponding 3-fluoronitrobenzene and 3-nitrotoluene with 1,1,1-trimethylhydrazinium iodide and potassium tert.-butoxide in a suitable solvent, for example, DMSO, affording the corresponding 2-fluoro-6-nitroaniline and 2-methyl-6-nitroaniline. The anilines were then reacted with acetic anhydride in acetic acid, yielding N-(2-fluoro-6-nitrophenyl)acetamide and N-(2-methyl-6-nitrophenyl)acetamide, which were then cyclized with sodium hydrosulfite in aqueous 10% sodium hydroxide, providing the targeted 4-fluoro-1-hydroxy-2-methylbenzimidazole and 1-hydroxy-2,4-dimethylbenzimidazole (1). Examples 4 and 6 set forth in detail the foregoing method of preparing these intermediates from the corresponding acetamides, which are compositions of matter known in the art.

The preparation of Intermediate (1), 1-hydroxy-2,4,5-trimethylimidazole, is disclosed by Akagane et al (Bull. Chem. Soc. Japan, 1969, 3204). Another Intermediate (1), 1-hydroxy-2-methyl-4,5,6,7-tetrahydrobenzimidazole, was prepared using the method disclosed by Akagane et al, wherein the known intermediate 1,2-cyclohexanonemonoxime (Geissman et al, J. Org. Chem., 1946, 771) was treated with an appropriate aldehyde, for example acetaldehyde, and ammonium hydroxide in a suitable solvent, for example, ethanol or dioxane, affording the targeted 1-hydroxy-2-methyl-4,5,6,7-tetrahydrobenzimidazole (1). Example 12 sets forth in detail the foregoing method of preparing this intermediate from the known 1,2-cyclohexanonemonoxime.

Intermediate (2), for example 1-amino-4-fluoro-2-methylbenzimidazole, was prepared in a step-wise manner by cyclizing 2-fluoro-6-nitroaniline (set forth above) with iron filings and acetic anhydride in acetic acid, affording the corresponding 4-fluoro-2-methylbenzimidazole. The so-prepared 4-fluoro-2-methylbenzimidazole was in turn aminated with hydroxylamine-O-sulfonic acid under basic conditions in a suitable solvent, for example, THF and water, affording the corresponding 1-amino-4-fluoro-2-methylbenzimidazole (2). Example 5 sets forth in detail the foregoing method of preparing this intermediate from 4-fluoro-2-methylbenzimidazole, which is a composition of matter known in the art. Intermediate (2), 1-amino-2-methylbenzimidazole, was also prepared by the method set forth in Example 5, from the commercially available 2-methylbenzimidazole.

Intermediate (2), for example 1-amino-5-fluoro-2-methylbenzimidazole, was prepared in a stepwise manner using the method disclosed by Tschirret-Guth et al (J. Org. Chem. 1998, 63, 9711) wherein an appropriately substituted 2-fluoronitrobenzene, for example 2,5-difluoronitrobenzene, was reacted with hydrazine and then immediately with acetyl chloride, affording the corresponding 1-acetyl-2-(4-fluoro-2-nitrophenyl)hydrazine. Using the method disclosed by Sheng et al (J. Org. Chem. 1963, 28, 736), the so-prepared hydrazine was then reduced by hydrogenation and cyclized with, for example acetic acid, affording the corresponding (5-fluoro-2-methylbenzimidazol-1-yl)acetamide. The acetamide was then treated with 2N hydrochloric acid, followed by 10% aqueous sodium hydroxide, yielding the targeted 1-amino-5-fluoro-2-methylbenzimidazole (2). Example 8 sets forth in detail the foregoing method of preparing this intermediate.

Appropriately substituted alkyl alcohols (3) that find utility in the reaction with Intermediate (1) affording compounds of formula (I) were also prepared by methods known to one skilled in the art.

For example, for use in Reaction B set forth in Scheme 1, the alkyl alcohol 2-(3-chloro-4-n-butoxyphenyl)ethanol (3) was prepared in a step-wise manner by esterifying the commercially available 3-chloro-4-hydroxyphenylacetic acid with an alcohol, for example, ethanol, under acid catalysis with, for example, p-toluenesulfonic acid, affording the corresponding ethyl 3-chloro-4-hydroxyphenylacetate. The 4-hydroxyphenylacetate was in turn treated with sodium hydride, and then was reacted with an alkyl halide, for example 1-iodobutane, affording the corresponding ethyl 3-chloro-4-n-butoxyphenylacetate. The 4-n-butoxyphenylacetate was then treated with lithium aluminum hydride, affording the corresponding 2-(3-chloro-4-n-butoxyphenyl)ethanol (3). Example 1 sets forth in detail the foregoing methods of preparing this intermediate from ethyl 3-chloro-4-hydroxyphenylacetate, which is a composition of matter known in the art. An alternate preparation of 2-(3-chloro-4-n-butoxyphenyl)ethanol (3) from 3-chloro-4-hydroxyphenylacetic acid was realized by the alkylation of the acetic acid with an alkyl halide, for example 1-iodobutane, as set forth above, yielding the corresponding 3-chloro-4-n-butoxyphenylacetic acid. The so-prepared acetic acid was then treated with, for example borane-THF complex, affording the corresponding 2-(3-chloro-4-n-butoxyphenyl)ethanol (3). Example 1 sets forth in detail the foregoing methods of preparing this intermediate from 3-chloro-4-n-butoxyphenylacetic acid, which is a composition of matter known in the art.

Other alkyl alcohols (3) were also prepared by methods known to one skilled in the art for use in Reaction B set forth in Scheme 1. For example, the alkyl alcohol 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethanol (3) was prepared in a step-wise manner from commercially available 3,5-difluorophenylacetic acid by first converting the acetic acid to the corresponding 2-(3,5-difluorophenyl)ethanol by methods described above. The OH of the so-prepared ethanol was then protected by treating it with triisopropylsilyl chloride and imidazole in a suitable solvent, for example, methylene chloride, affording the corresponding tri(1-methylethyl)silyl 2-(3,5-difluorophenyl)ethyl ether, which was in turn treated with n-butyllithium in a suitable solvent, for example, THF at depressed temperature, and then reacted with DMF, yielding the corresponding 2,6-difluoro-4-[2-[tri(1-methylethyl)silyloxy]ethyl]benzaldehyde. The aldehyde was then reacted with, for example, O-ethylhydroxylamine hydrochloride, providing the corresponding tri(1-methylethyl)silyl 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethyl ether. The tri(1-methylethyl)silyl moiety was then cleaved by treating the ether with tetrabutylammonium fluoride, yielding the unprotected alcohol, 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethanol (3). Example 9 sets forth in detail the foregoing method of preparing this intermediate.

When advantageous, appropriately substituted alkyl halides (3) were reacted, according to Reaction C as set forth in Scheme 1, with Intermediate (1) affording compounds of formula (I). The useful alkyl halides (3) were also prepared by methods known by one skilled in the art. For example, the alkyl halide 2-[3-chloro-4-(1,1-dimethylethyl)phenyl]ethyl bromide (3) was prepared from commercially available 2-[3-chloro-4-(1,1-dimethylethyl)phenyl]ethanol by bromination of the ethanol with phosphorous tribromide in a suitable solvent, for example, methylene chloride, affording the corresponding ethyl bromide (3). Example 2 sets forth in detail the use of this known composition of matter to prepare compounds of formula (I).

Appropriately substituted alkyl aldehydes (4) that find utility in the reaction with Intermediate (2) affording compounds of formula (I) were also prepared by methods known to one skilled in the art.

For example, for use in Reaction D set forth in Scheme 1, the alkyl aldehyde 3-chloro-4-n-butoxyphenylacetaldehyde (4) was prepared from 2-(3-chloro-4-n-butoxyphenyl)ethanol (described above) by treating the ethanol with dichlorotris(triphenylphosphine)ruthenium(II) and iodobenzene diacetate in a suitable solvent, for example, methylene chloride, affording the corresponding 3-chloro-4-n-butoxyphenylacetaldehyde (3). Example 3 sets forth in detail the foregoing method of preparing this intermediate.

An additional alkyl aldehyde (4), for example, 4-n-butoxy-3,5-dimethylphenylacetaldehyde, was prepared in a step-wise manner from commercially available 3,5-dimethyl-4-hydroxybenzaldehyde by first reacting the benzaldehyde with, for example, 1-iodobutane under basic conditions, yielding the corresponding 4-n-butoxy-3,5-dimethylbenzaldehyde. The so-prepared benzaldehyde was then reacted with the ylide derived from (methoxymethyl)triphenylphosphonium chloride and sodium hydride in a suitable solvent, for example, THF, affording the corresponding 1-(4-n-butoxy-3,5-dimethylphenyl)-2-methoxyethene, which was in turn reacted with hydrochloric acid in a suitable solvent, for example, acetonitrile, affording the corresponding 4-n-butoxy-3,5-dimethylphenylacetaldehyde (4). Example 7 sets forth in detail the foregoing method of preparing this intermediate.

Also, the alkyl aldehyde (4), propyl 2-chloro-4-formylmethylbenzoate was prepared in a step-wise manner by first chlorinating the known ethyl (4-aminophenyl)acetate with N-chlorosuccinimide, affording the corresponding ethyl (3-chloro-4-aminophenyl)acetate. The 3-chloro derivative was then treated with tert.-butyl nitrite and copper(II) bromide, yielding the brominated intermediate, ethyl (4-bromo-3-chlorophenyl)acetate, which was in turn treated with diisobutylaluminum hydride, affording the corresponding 4-bromo-3-chlorophenylacetaldehyde. The carbonyl moiety of the aldehyde was then protected by treating it with p-toluenesulfonic acid and 1,2-ethanediol, affording the corresponding 2-[(4-bromo-3-chlorophenyl)methyl]-1,3-dioxolane. Treatment of the dioxolane with n-butyllithium and carbon dioxide gave the corresponding lithium 2-chloro-4-(1,3-dioxolan-1-ylmethyl)benzoate, which was then reacted with, for example, n-propyl bromide, yielding propyl 2-chloro-4-(1,3-dioxolan-1-ylmethyl)benzoate. The 1,3-dioxolan-1-yl moiety was then cleaved from the so-prepared propyl benzoate by treating it with dilute hydrochloric acid, affording the corresponding unprotected aldehyde compound, propyl 2-chloro-4-formylmethylbenzoate (4). Example 10 sets forth in detail the foregoing method of preparing this intermediate from 4-bromo-3-chlorophenylacetaldehyde, which is a composition of matter known in the art.

Also, the alkyl aldehyde (4), 2-methyl-2-(4-n-butoxyphenyl)propionaldehyde was prepared in a step-wise manner by first alkylating the commercially available 4-hydroxyphenylacetonitrile with, for example, 1-iodobutane and potassium carbonate, affording the corresponding 4-n-butoxyphenylacetonitrile, The alkylated acetonitrile was in turn treated with potassium tert.-butoxide in a suitable solvent, for example, THF, then reacted with, for example, methyl iodide, affording the corresponding 2-methyl-2-(4-n-butoxyphenyl)propionitrile. The so-prepared propionitrile was then reduced with diisobutylaluminum hydride in a suitable solvent, for example, toluene, yielding 2-methyl-2-(4-n-butoxyphenyl)propionaldehyde (4). Example 14 sets forth in detail the foregoing method of preparing this intermediate from 2-methyl-2-(4-n-butoxyphenyl)propionitrile, which is a composition of matter known in the art.

It is contemplated that in the reaction of, for example, Intermediate (1) with an appropriately substituted alkyl alcohol (3) or alkyl halide (3), or of Intermediate (2) with an appropriately substituted alkyl aldehyde (4), that more than one targeted compound of formula (I) can be formed. For example, in the reaction of Intermediate (2), 1-amino-2-methylbenzimidazole, and Intermediate (4), 2-methyl-2-(4-n-butoxyphenyl)propionaldehyde, by methods described above, two compounds of formula (I) were prepared and isolated. Example 14 sets forth in detail the preparation and isolation of 1-[[2-methyl-2-(4-n-butoxyphenyl)propyl]amino]-2-methylbenzimidazole (where W is amino) and 1-[[2-methyl-2-(4-n-butoxyphenyl)propyl]imino]-2-methylbenzimidazole (where W is N═).

Certain compounds of formula (I) can be further reacted to obtain other compounds of formula (I). For example, 1-[2-(4-methoxyphenyl)ethoxy]-2,4-dimethylbenzimidazole (I) was treated with boron tribromide, affording the corresponding 1-[2-(4-hydroxyphenyl)ethoxy]-2,4-dimethylbenzimidazole, which was in turn reacted with 4-heptanol, triphenylphosphine, and DEAD in THF, yielding the targeted 1-[2-[4-(1-propylbutoxy)phenyl]ethoxy]-2,4-dimethylbenzimidazole (I). Example 11 sets forth in detail the preparation of this compound.

The present invention also relates to insecticidal compositions that combine insecticidally effective amounts of the active compounds with adjuvants and carriers normally employed in the art for facilitating the dispersion of active ingredients for the particular utility desired. One skilled in the art will of course recognize that the formulation and mode of application of a toxicant may affect the activity of the material in a given application. Thus, for agricultural use the present insecticidal compounds may be formulated as a granular of relatively large particle size (for example, 8/16 or 4/8 US Mesh), as water-soluble or water-dispersible granules, as powdery dusts, as wettable powders, as emulsifiable concentrates, as aqueous emulsions, as solutions, or as any of other known types of agriculturally-useful formulations, depending on the desired mode of application. It is to be understood that the amounts specified in this specification are intended to be approximate only, as if the word “about” were placed in front of the amounts specified.

These insecticidal compositions may be applied either as water-diluted sprays, or dusts, or granules to the areas in which suppression of insects is desired. These formulations may contain as little as 0.1%, 0.2% or 0.5% to as much as 95% or more by weight of active ingredient.

Dusts are free flowing admixtures of the active ingredient with finely divided solids such as talc, natural clays, kieselguhr, flours such as walnut shell and cottonseed flours, and other organic and inorganic solids which act as dispersants and carriers for the toxicant; these finely divided solids have an average particle size of less than about 50 microns. A typical dust formulation useful herein is one containing 1.0 part or less of the insecticidal compound and 99.0 parts of talc.

Wettable powders, also useful formulations for insecticides, are in the form of finely divided particles which disperse readily in water or other dispersant. The wettable powder is ultimately applied to the locus where insect control is needed either as a dry dust or as an emulsion in water or other liquid. Typical carriers for wettable powders include Fuller's earth, kaolin clays, silicas, and other highly absorbent, readily wet inorganic diluents. Wettable powders normally are prepared to contain about 5-80% of active ingredient, depending on the absorbency of the carrier, and usually also contain a small amount of a wetting, dispersing or emulsifying agent to facilitate dispersion. For example, a useful wettable powder formulation contains 80.0 parts of the insecticidal compound, 17.9 parts of Palmetto clay, and 1.0 part of sodium lignosulfonate and 0.3 part of sulfonated aliphatic polyester as wetting agents. Additional wetting agent and/or oil will frequently be added to a tank mix for to facilitate dispersion on the foliage of the plant.

Other useful formulations for insecticidal applications are emulsifiable concentrates (ECs) which are homogeneous liquid compositions dispersible in water or other dispersant, and may consist entirely of the insecticidal compound and a liquid or solid emulsifying agent, or may also contain a liquid carrier, such as xylene, heavy aromatic naphthas, isphorone, or other non-volatile organic solvents. For insecticidal application these concentrates are dispersed in water or other liquid carrier and normally applied as a spray to the area to be treated. The percentage by weight of the essential active ingredient may vary according to the manner in which the composition is to be applied, but in general comprises 0.5 to 95% of active ingredient by weight of the insecticidal composition.

Flowable formulations are similar to ECs except that the active ingredient is suspended in a liquid carrier, generally water. Flowables, like ECs, may include a small amount of a surfactant, and will typically contain active ingredients in the range of 0.5 to 95%, frequently from 10 to 50%, by weight of the composition. For application, flowables may be diluted in water or other liquid vehicle, and are normally applied as a spray to the area to be treated.

Typical wetting, dispersing or emulsifying agents used in agricultural formulations include, but are not limited to, the alkyl and alkylaryl sulfonates and sulfates and their sodium salts; alkylaryl polyether alcohols; sulfated higher alcohols; polyethylene oxides; sulfonated animal and vegetable oils; sulfonated petroleum oils; fatty acid esters of polyhydric alcohols and the ethylene oxide addition products of such esters; and the addition product of long-chain mercaptans and ethylene oxide. Many other types of useful surface-active agents are available in commerce. Surface-active agents, when used, normally comprise 1 to 15% by weight of the composition.

Other useful formulations include suspensions of the active ingredient in a relatively non-volatile solvent such as water, corn oil, kerosene, propylene glycol, or other suitable solvents.

Still other useful formulations for insecticidal applications include simple solutions of the active ingredient in a solvent in which it is completely soluble at the desired concentration, such as acetone, alkylated naphthalenes, xylene, or other organic solvents. Granular formulations, wherein the toxicant is carried on relative coarse particles, are of particular utility for aerial distribution or for penetration of cover crop canopy. Pressurized sprays, typically aerosols wherein the active ingredient is dispersed in finely divided form as a result of vaporization of a low-boiling dispersant solvent carrier may also be used. Water-soluble of water-dispersible granules are free flowing, non-dusty, and readily water-soluble or water-miscible. In use by the farmer on the field, the granular formulations, emulsifiable concentrates, flowable concentrates, aqueous emulsions, solutions, etc., may be diluted with water to give a concentration of active ingredient in the range of say 0.1% or 0.2% to 1.5% or 2%.

The active insecticidal compounds of this invention may be formulated and/or applied with one or more second compounds. Second compounds include, but are not limited to, other pesticides, plant growth regulators, fertilizers, soil conditioners, or other agricultural chemicals. In applying an active compound of this invention, whether formulated alone or with other agricultural chemicals, an effective amount and concentration of the active compound is of course employed; the amount may vary in the range of, e.g. about 0.01 to about 3 kg/ha, preferably about 0.03 to about 1 kg/ha. For field use, where there are losses of insecticide, higher application rates (e.g., four times the rates mentioned above) may be employed.

When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other pesticides such as herbicides, the herbicides include, without limitation, for example: N-(phosphonomethyl)glycine (“glyphosate”); aryloxyalkanoic acids such as (2,4-dichlorophenoxy)acetic acid (“2,4-D”), (4-chloro-2-methylphenoxy)acetic acid (“MCPA”), (+/−)-2-(4chloro-2-methylphenoxy)propanoic acid (“MCPP”); ureas such as N,N-dimethyl-N′-[4-(1-methylethyl)phenyl]urea (“isoproturon”); imidazolinones such as 2-[4,5-d]hydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-3-pyridinecarboxylic acid (“imazapyr”), a reaction product comprising (+/−)-2-[4,5-d]hydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-4-methylbenzoic acid and (+/−)2-[4,5-d]hydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-methylbenzoic acid (“imazamethabenz”), (+/−)-2-[4,5-d]hydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-ethyl-3-pyridinecarboxylic acid (“imazethapyr”), and (+/−)-2-[4,5-d]hydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-3-quinolinecarboxylic acid (“imazaquin”); diphenyl ethers such as 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid (“acifluorfen”), methyl 5-(2,4-dichlorophenoxy)-2-nitrobenzoate (“bifenox”), and 5-[2-chloro-4-(trifluoromethyl)phenoxy]-N-(methylsulfonyl)-2-nitrobenzamide (“fomasafen”); hydroxybenzonitriles such as 4-hydroxy-3,5-diiodobenzonitrile (“ioxynil”) and 3,5-dibromo-4-hydroxybenzonitrile (“bromoxynil”); sulfonylureas such as 2-[[[[[(4chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid (“chlorimuron”), 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide (achlorsulfuron”), 2-[[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]methyl]benzoic acid (“bensulfuron”), 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-1-methyl-1H-pyrazol-4-carboxylic acid (“pyrazosulfuron”), 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]-2-thiophenecarboxylic acid (“thifensulfuron”), and 2-(2-chloroethoxy)-N[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide (“triasulfuron”); 2-(4-aryloxy-phenoxy)alkanoic acids such as (+/−)-2[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]-propanoic acid (fenoxaprop”), (+/−)-2-[4[[5-(trifluoromethyl)-2-pyridinyl]oxy]-phenoxy]propanoic acid (“fluazifop”), (+/−)-2-[4-(6-chloro-2-quinoxalinyl)oxy]-phenoxy]propanoic acid (“quizalofop”), and (+/−)-2-[(2,4-dichlorophenoxy)phenoxy]propanoic acid (“diclofop”); benzothiadiazinones such as 3-(1-methylethyl)-1H-1,2,3-benzothiadiazin-4(3H)-one-2,2-dioxide (“bentazone”); 2-chloroacetanilides such as N-(butoxymethyl)-2-chloro-N-(2,6-diethylphenyl)acetamide (“butachlor”), 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide (“metolachlor”), 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide (“acetochlor”), and (RS)-2-chloro-N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)acetamide (“dimethenamide”); arenecarboxylic acids such as 3,6-dichloro-2-methoxybenzoic acid (“dicamba”); pyridyloxyacetic acids such as [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy]acetic acid (“fluoroxypyr”), and other herbicides.

When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other pesticides such as other insecticides, the other insecticides include, for example: organophosphate insecticides, such as chlorpyrifos, diazinon, dimethoate, malathion, parathion-methyl, and terbufos; pyrethroid insecticides, such as fenvalerate, deltamethrin, fenpropathrin, cyfluthrin, flucythrinate, alpha-cypermethrin, biphenthrin, resolved cyhalothrin, etofenprox, esfenvalerate, tralomehtrin, tefluthrin, cycloprothrin, betacyfluthrin, and acrinathrin; carbamate insecticides, such as aldecarb, carbaryl, carbofuran, and methomyl; organochlorine insecticides, such as endosulfan, endrin, heptachlor, and lindane; benzoylurea insecticides, such as diflubenuron, triflumuron, teflubenzuron, chlorfluazuron, flucycloxuron, hexaflumuron, flufenoxuron, and lufenuron; and other insecticides, such as amitraz, clofentezine, fenpyroximate, hexythiazox, and imidacloprid.

When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other pesticides such as fungicides, the fungicides include, for example: benzimidazole fungicides, such as benomyl, carbendazim, thiabendazole, and thiophanate-methyl; 1,2,4-triazole fungicides, such as epoxyconazole, cyproconazole, flusilazole, flutriafol, propiconazole, tebuconazole, triadimefon, and triadimenol; substituted anilide fungicides, such as metalaxyl, oxadixyl, procymidone, and vinclozolin; organophosphorus fungicides, such as fosetyl, iprobenfos, pyrazophos, edifenphos, and tolclofos-methyl; morpholine fungicides, such as fenpropimorph, tridemorph, and dodemorph; other systemic fungicides, such as fenarimol, imazalil, prochloraz, tricyclazole, and triforine; dithiocarbamate fungicides, such as mancozeb, maneb, propineb, zineb, and ziram; non-systemic fungicides, such as chlorothalonil, dichlofluanid, dithianon, and iprodione, captan, dinocap, dodine, fluazinam, gluazatine, PCNB, pencycuron, quintozene, tricylamide, and validamycin; inorganic fungicides, such as copper and sulphur products, and other fungicides.

When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other pesticides such as nematicides, the nematicides include, for example: carbofuran, carbosulfan, turbufos, aldecarb, ethoprop, fenamphos, oxamyl, isazofos, cadusafos, and other nematicides.

When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other materials such as plant growth regulators, the plant growth regulators include, for example: maleic hydrazide, chlormequat, ethephon, gibberellin, mepiquat, thidiazon, inabenfide, triaphenthenol, paclobutrazol, unaconazol, DCPA, prohexadione, trinexapac-ethyl, and other plant growth regulators.

Soil conditioners are materials which, when added to the soil, promote a variety of benefits for the efficacious growth of plants. Soil conditioners are used to reduce soil compaction, promote and increase effectiveness of drainage, improve soil permeability, promote optimum plant nutrient content in the soil, and promote better pesticide and fertilizer incorporation. When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other materials such as soil conditioners, the soil conditioners include organic matter, such as humus, which promotes retention of cation plant nutrients in the soil; mixtures of cation nutrients, such as calcium, magnesium, potash, sodium, and hydrogen complexes; or microorganism compositions which promote conditions in the soil favorable to plant growth. Such microorganism compositions include, for example, bacillus, pseudomonas, azotobacter, azospirillum, rhizobium, and soil-borne cyanobacteria.

Fertilizers are plant food supplements, which commonly contain nitrogen, phosphorus, and potassium. When the active insecticidal compounds of the present invention are used in combination with one or more of second compounds, e.g., with other materials such as fertilizers, the fertilizers include nitrogen fertilizers, such as ammonium sulfate, ammonium nitrate, and bone meal; phosphate fertilizers, such as superphosphate, triple superphosphate, ammonium sulfate, and diammonium sulfate; and potassium fertilizers, such as muriate of potash, potassium sulfate, and potassium nitrate, and other fertilizers.

The following examples further illustrate the present invention, but, of course, should not be construed as in any way limiting its scope. The examples are organized to present protocols for the synthesis of the diazole and triazole derivatives of the present invention, set forth a list of such synthesized species, and set forth certain biological data indicating the efficacy of such compounds.

EXAMPLE 1 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethoxy]-2-methylbenzimidazole (Compound 163 in Table Below) Step A Synthesis of 2-(3-chloro-4-n-butoxyphenyl)ethanol as an Intermediate

A stirred solution of 20 mL of 1.0M lithium aluminum hydride (0.02 mole-in THF) was cooled to below 10° C., and a solution of 5.0 grams (0.019 mole) of ethyl 3-chloro-4-n-butoxyphenylacetate (a known compound) in 10 mL of THF was added dropwise at a rate to maintain the reaction mixture temperature at about 10° C. Upon completion of addition, the reaction mixture was stirred for about 3 hours. Water, 5 ml, was then added dropwise, which caused an exothermic reaction and evolution of hydrogen. The reaction mixture thickened and stirring became difficult. Vigorous stirring continued, and 10 mL of 3M hydrochloric acid was added dropwise. During the addition, the thickness of the reaction mixture dissipated. Upon completion of addition, the reaction mixture was extracted with two 100 mL portions of ethyl acetate. The extracts were combined and washed with two 50 mL portions of aqueous 3M hydrochloric acid, then with two 50 mL portions of an aqueous solution of saturated sodium chloride. The organic layer was dried with magnesium sulfate, filtered and evaporated under reduced pressure, yielding 4.0 g of the subject compound. The NMR spectrum was consistent with the proposed structure.

Synthesis of 2-(3-chloro-4-n-butoxyphenyl)ethanol as an Intermediate, Alternate Method

Under a nitrogen atmosphere, a stirred solution of 3.0 grams (0.012 mole) of (4-n-butoxy-3-chlorophenyl)acetic acid (known compound) in 25 mL of THF was cooled to about 10° C. and 16 mL of a solution of 1M borane-THF complex (in THF) was added dropwise during a 25 minute period. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature where it stirred for about two hours. After this time, 10 mL of aqueous 3N sodium hydroxide was slowly added, then the reaction mixture was stirred for about 15 minutes. After this time the reaction mixture was poured into 50 mL of an aqueous solution saturated with sodium bicarbonate, then extracted with two 50 mL portions of diethyl ether. The combined extracts were washed with an aqueous solution saturated with sodium chloride, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to a residual oil. The oil was purified by column chromatography on silica gel using mixtures of heptane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 2.5 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of Compound 163

A solution of 0.40 gram (0.0027 mole) of 1-hydroxy-2-methylbenzimidazole (known compound), 0.61 gram (0.0027 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol, and 0.85 gram (0.0027 mole) of triphenylphosphine in 10 mL of THF was stirred, and 0.5 gram (0.0027 mole) of DEAD was added. Upon completion of addition, the reaction mixture stirred at ambient temperature for about 18 hours. After this time the reaction mixture was poured, with stirring, into 150 mL of aqueous 10% sodium hydroxide. The mixture was extracted with three 50 mL portions of heptane. The combined extracts were washed with one 100 mL portion of water, then with one 100 mL portion of an aqueous solution saturated with sodium chloride. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, yielding an oil. The oil was purified by column chromatography on silica gel using mixtures of methylene chloride and methanol. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.77 gram of Compound 163. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 2 This Example Illustrates One Protocol for the Preparation of 1-[2-[3-chloro-4-(1,1-dimethylethyl)phenyl]ethoxy]-2-methylbenzimidazole (Compound 135 in Table Below)

A solution of 0.49 gram (0.003 mole) of 1-hydroxy-2-methylbenzimidazole, 0.75 gram (0.003 mole) of 2-[3-chloro-4-(1,1-dimethylethyl)phenyl]ethyl bromide (known compound), 0.55 gram (0.004 mole) of potassium carbonate, and 5 mL of DMF in 30 mL of acetone was stirred at ambient temperature for about 18 hours. After this time the reaction mixture was concentrated under reduced pressure to a residue. The residue was taken up in 50 mL of methylene chloride and filtered through silica gel. The filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using mixtures of heptane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.52 gram of Compound 135. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 3 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethylamino]-2-methylbenzimidazole (Compound 314 in Table Below) Step A Synthesis of 3-chloro-4-n-butoxyphenylacetaldehyde as an Intermediate

Under a nitrogen atmosphere, a solution of 10.0 grams (0.044 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol (prepared in accordance with Step A of Example 1) and 2.0 grams (0.002 mole) of dichlorotris(triphenylphosphine)ruthenium(II) in 100 mL of methylene chloride was stirred and a solution of 15.6 grams (0.048 mole) of iodobenzene diacetate in 50 mL of methylene chloride was added dropwise during a one hour period. Upon completion of addition the reaction mixture was stirred for an additional three hours. After this time the reaction mixture was washed with one 100 mL portion of an aqueous solution saturated with sodium chloride, dried with magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure to an oil residue. The residue was purified by column chromatography on silica gel using mixtures of heptane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 4.5 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of Compound 314

Under a nitrogen atmosphere, a stirred solution of 2.7 grams (0.012 mole) of 3-chloro-4-n-butoxyphenylacetaldehyde, 2.1 grams (0.014 mole) of 1-amino-2-methylbenzimidazole (known compound), and 2.4 grams (0.040 mole) of acetic acid in 60 mL of ethanol was heated under gentle reflux for about two hours. After this time, a solution of 1.0 gram (0.016 mole) of sodium cyanoborohydride in 10 mL of ethanol was added during a 10 minute period. Upon completion of addition, the reaction mixture was stirred at reflux for an additional two hours. After this time the reaction mixture was cooled and concentrated under reduced pressure to a residue. The residue was taken up in 75 mL of an aqueous solution saturated with sodium bicarbonate, and the mixture was extracted with three 60 mL portions of ethyl acetate. The combined extracts were washed with one portion of an aqueous solution saturated with sodium chloride, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to an oil residue. The residue was purified by column chromatography on silica gel using mixtures of heptane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 2.3 grams of Compound 314. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 4 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethoxy]-4-fluoro-2-methylbenzimidazole (Compound 246 in Table Below) Step A Synthesis of 4-fluoro-1-hydroxy-2-methylbenzimidazole as an Intermediate

A stirred solution of 0.84 gram (0.004 mole) of N-(2-fluoro-6-nitrophenyl)acetamide (known compound) in 30 mL of aqueous 10% sodium hydroxide was cooled to about 5° C., and 2.1 grams (0.012 mole) of sodium hydrosulfite was added in about three equal portions about five minutes apart. Upon completion of addition, the reaction mixture was stirred at about 5-10° C. for 1.5 hours. After this time, about 2.0 grams of ammonium chloride, followed by about 5 mL of aqueous 1N hydrochloric acid were added to the reaction mixture. The volume of the reaction mixture was reduced to about two-thirds under reduced pressure, then the reaction mixture was extracted with five 40 mL portions of ethyl acetate. The combined extracts were dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to an oily solid residue. The solid was triturated with two 40 mL portions of heptane, yielding about 0.3 gram of subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of Compound 246

This compound was prepared in accordance with the method of Example 1, Step B, using 0.30 gram (0.0018 mole) of 4-fluoro-1-hydroxy-2-methylbenzimidazole, 0.41 gram (0.0018 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol, 0.52 gram (0.0020 mole) of triphenylphosphine, and 0.35 gram (0.0020 mole) of DEAD in 30 ml of THF. The product was purified by column chromatography on silica gel using mixtures of heptane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.17 gram of Compound 246. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 5 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethylamino]-4-fluoro-2-methylbenzimidazole (Compound 323 in Table Below) Step A Synthesis of 1-amino-4-fluoro-2-methylbenzimidazole as an Intermediate

Under a nitrogen atmosphere, a stirred solution of 1.0 gram (0.007 mole) of 4-fluoro-2-methylbenzimidazole (known compound) and 2.0 grams (0.036 mole) of potassium hydroxide in 30 mL of 20/1-water/THF was cooled in a cold water bath, and 1.1 grams (0.010 mole) of hydroxylamine-O-sulfonic acid was added in about four equal portions during a 20 minute period. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature, where it stirred for about 18 hours. After this time a solid precipitate was collected by filtration, washed with water, and dried under vacuum. The solid was triturated with 50 mL of 2/1-ethyl acetate/methanol, and the triturate was concentrated, yielding 0.33 gram of product, which according to the NMR spectrum, consisted of about a 1/1 mixture of the proposed 4-fluorobenzimidazole and its isomer, the 7-fluorobenzimidazole.

The isolated product was combined with the isolated product of another run of this reaction. The 4-fluorobenzimidazole and 7-fluorobenzimidazole isomers of the combination were separated by column chromatography on alumina using mixtures of heptane and ethyl acetate. The appropriate fractions containing each isomer were combined and concentrated under reduced pressure, yielding 0.65 gram of the 7-fluorobenzimidazole isomer, and 0.54 gram of the 4-fluorobenzimidazole isomer. The NMR spectra were consistent with the proposed structures.

Step B Synthesis of Compound 323

This compound was prepared in accordance with the method of Example 3, Step B, using 0.4 gram (0.002 mole) of 3-chloro-4-n-butoxyphenylacetaldehyde, 0.5 gram (0.014 mole) of 1-amino-4-fluoro-2-methylbenzimidazole, 2.0 mL (excess) of acetic acid, and 0.33 gram (0.005 mole) of sodium cyanoborohydride in 20 mL of ethanol. The product was purified by column chromatography on silica gel using mixtures of heptane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.31 gram of Compound 323. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 6 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethoxy]-2,4-dimethylbenzimidazole (Compound 266 in Table Below) Step A Synthesis of 1-hydroxy-2,4-dimethylbenzimidazole as an Intermediate

In a method analogous to that of Step A of Example 4, A freshly prepared solution of 200 mL of 10% aqueous sodium hydroxide was vigorously stirred, and 9.0 grams (0.046 mole) of N-(2-methyl-6-nitrophenyl)acetamide (known compound) was added. To this was then added 15.5 grams (0.089 mole) of sodium hydrosulfite in one-to-two gram portions, at a rate to keep the reaction mixture temperature below 40° C. Upon completion of addition, the reaction mixture was stirred for about 20 to 30 minutes, during which time the reaction went to completion. The reaction mixture was cooled, then treated with concentrated hydrochloric acid until a solid precipitate formed. The reaction mixture was filtered to remove the solid; the filtrate was saturated with sodium chloride and extracted with three 100 mL portions of THF. The combined extracts were dried with magnesium sulfate, and the mixture was filtered. The filtrate was concentrated under reduced pressure, yielding 4.2 grams of subject compound.

Step B Synthesis of Compound 266

This compound was prepared in accordance with the method of Example 1, Step B, using 1.2 grams (0.0073 mole) of 1-hydroxy-2,4-dimethylbenzimidazole, 1.5 grams (0.0066 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol, 1.9 grams (0.0072 mole) of triphenylphosphine, and 1.3 mL (0.0076 mole) of DEAD in 20 mL of THF. The product was purified by column chromatography on silica gel using mixtures of methylene chloride and methanol. The fractions containing product were combined and concentrated under reduced pressure, yielding 2.3 grams of Compound 266. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 7 This Example Illustrates One Protocol for the Preparation of 1-[2-(3,5-dimethyl-4-n-butoxyphenyl)ethylamino]-2-methylbenzimidazole (Compound 320 in Table Below) Step A Synthesis of 4-n-butoxy-3,5-dimethylbenzaldehyde as an Intermediate

A mixture of 5.0 grams (0.0332 mole) of 3,5-dimethyl-4-hydroxybenzaldehyde and 9.0 grams (0.0664 mole) of potassium carbonate in 50 mL of DMF was stirred, and 6.1 grams (0.0332 mole) of 1-iodobutane was added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for about 18 hours. The reaction mixture was then poured into 200 mL of an aqueous solution saturated with sodium chloride and extracted with three 100 mL portions of ethyl acetate. The combined extracts were washed with three 30 mL portions of water, then with three 30 mL portions of an aqueous solution saturated with sodium chloride. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, yielding 6.1 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of 1-(4-n-butoxy-3,5-dimethylphenyl)-2-methoxyethene as an Intermediate

A mixture of 7.5 grams (0.0216 mole) of (methoxymethyl)triphenylphosphonium chloride and 0.85 gram (0.0216 mole) of 60% sodium hydride in 50 mL of THF was stirred for 30 minutes at ambient temperature. The mixture was then cooled to about 0° C., and a solution of 3.0 grams (0.0144 mole) of 4-n-butoxy-3,5-dimethylbenzaldehyde in 10 mL of THF was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature where it stirred for about 18 hours. The reaction mixture was then poured into 100 mL of water and extracted with three 100 mL portions of diethyl ether. The combined extracts were dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was taken up in about 30 mL of hexanes and passed through a pad of silica gel. The filtrate was concentrated under reduced pressure, yielding 2.6 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step C Synthesis of 4-n-butoxy-3,5-dimethylphenylacetaldehyde as an intermediate

A stirred solution of 2.0 grams (0.0085 mole) of 1-(4-n-butoxy-3,5-dimethylphenyl)-2-methoxyethene and 2.4 mL of aqueous 1N hydrochloric acid in 9.6 mL of acetonitrile was heated at 60° C. for six hours, then it was allowed to cool to ambient temperature where it stirred for about 18 hours. The reaction mixture was poured into 100 mL of aqueous dilute solution of sodium bicarbonate, and was extracted with three 100 mL portions of diethyl ether. The combined extracts were dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using mixtures of hexanes and diethyl ether. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.8 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step D Synthesis of Compound 320

This compound was prepared in accordance with the method of Example 3, Step B, using 0.6 gram (0.0027 mole) of 4-n-butoxy-3,5-dimethylphenylacetaldehyde, 0.6 gram (0.041 mole) of 1-amino-2-methylbenzimidazole, 1.0 mL of acetic acid, and 0.38 gram (0.0062 mole) of sodium cyanoborohydride in 30 mL of ethanol. The product was purified by column chromatography on silica gel using mixtures of methylene chloride and methanol. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.55 gram of Compound 320. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 8 This Example Illustrates One Protocol for the Preparation of 1-[2-(3,5-dimethyl-4-n-butoxyphenyl)ethylamino]-5-fluoro-2-methylbenzimidazole (Compound 329 in Table Below) Step A Synthesis of 1-acetyl-2-(4-fluoro-2-nitrophenyl)hydrazine as an Intermediate

Under a nitrogen atmosphere, a solution of 4.8 grams (0.030 mole) of 2,5-difluoronitrobenzene and 5.4 mL (0.066 mole) of pyridine in 40 mL of acetonitrile was stirred, and 1.1 mL (0.033 mole) anhydrous hydrazine was added. Upon completion of addition, the reaction mixture was stirred for about 15 minutes and 2.5 mL (0.035 mole) of acetyl chloride was added. The addition caused an exothermic reaction, which caused the reaction mixture temperature to rise to about 55° C. The reaction mixture was allowed to cool to about ambient temperature, and the solvent was removed under vacuum. The residue was taken up in 200 mL of water and 100 mL of methylene chloride. The layers were separated and the aqueous layer was extracted with two 100 mL portions of methylene chloride. The organic layers were combined and dried with magnesium sulfate. The mixture was filtered and the filtrate was subjected to column chromatography by pouring the filtrate into about 500 mL of silica gel in a 600 mL sintered glass funnel. Unreacted 2,5-difluoronitrobenzene was collected by elution with about 1000 mL of methylene chloride. The proposed product was then collected by elution with about 2500 mL of 1:1 ethyl acetate: methylene chloride. The eluant containing the proposed product was concentrated under reduced pressure, yielding about 0.8 gram of that material. The NMR spectrum was consistent with the proposed structure. The reaction was repeated in order to isolate additional product.

Step B Synthesis of (5-fluoro-2-methylbenzimidazol-1-yl)acetamide as an Intermediate

A mixture of 5.1 grams (0.0240 mole) of 1-acetyl-2-(4-fluoro-2-nitrophenyl)hydrazine and 0.5 gram (catalyst) of 5% palladium on carbon in 100 mL of acetic acid was hydrogenated using a Parr hydrogenator. Following the theoretical uptake amount of hydrogen gas, the mixture was filtered and the filtrate was immediately heated under a nitrogen atmosphere to reflux, where it stirred for about 18 hours. The acetic acid was then removed under vacuum to leave a residue, which was dried at about 60° C. for one hour. The residue was purified by column chromatography on neutral alumina using methylene chloride and mixtures of methylene chloride and methanol. The fractions containing product were combined and concentrated under reduced pressure, yielding 2.2 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step C Synthesis of 1-amino-5-fluoro-2-methylbenzimidazole as an Intermediate

A solution of 2.2 grams (0.011 mole) of (5-fluoro-2-methylbenzimidazol-1-yl)acetamide in 10 mL of methanol was stirred, and about 200 mL of aqueous 2N hydrochloric acid was added. The mixture was heated at reflux for about 30 minutes, and then it was cooled to ambient temperature. The mixture was extracted with one 100 mL portion of methylene chloride and one 100 mL portion of ethyl acetate. The aqueous solution was made basic with 200 mL of aqueous 10% sodium hydroxide, and then it was extracted with four 100 mL portions of ethyl acetate. The combined extracts were concentrated under reduced pressure to a residue. The residue was dried under vacuum at 60° C., yielding 1.7 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step D Synthesis of Compound 329

This compound was prepared in accordance with the method of Example 3, Step B, using 0.76 gram (0.0034 mole) of 4-n-butoxy-3,5-dimethylphenylacetaldehyde, 0.50 gram (0.034 mole) of 1-amino-5-fluoro-2-methylbenzimidazole, 0.05 gram of p-toluenesulfonic acid, 0.36 gram (0.0057 mole) of sodium cyanoborohydride and 2 mL of ethanol in 25 mL of toluene. The product was purified by column chromatography on silica gel using 10% acetone in methylene chloride. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.70 gram of Compound 329. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 9 This Example Illustrates One Protocol for the Preparation of 1-[2-(3,5-difluoro-4-ethoxyiminomethylphenyl)ethoxy]-2-methylbenzimidazole (Compound 1323 in Table Below) Step A Synthesis of 2-(3,5-difluorophenyl)ethanol as an Intermediate

A stirred solution of 10.0 grams (0.058 mole) of 3,5-difluorophenylacetic acid in 100 mL of THF was cooled to about 5° C., and 80 mL of a 1.0M solution of borane-THF complex (in 80 mL of THF) was added dropwise, while maintaining the reaction mixture temperature between about 5° C. and about 10° C. Upon completion of addition, the reaction mixture was stirred as it warmed to ambient temperature. After this time the reaction mixture was treated with a solution of 7.5 grams of sodium hydroxide in 100 mL of water. The mixture was extracted with two 200 mL portions of diethyl ether, and the combined extracts were dried with magnesium sulfate. The mixture was filtered and the filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using mixtures of methylene chloride and diethyl ether. The fractions containing product were combined and concentrated under reduced pressure, yielding 8.6 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of tri(1-methylethyl)silyl 2-(3,5-difluorophenyl)ethyl ether as an Intermediate

A solution of 8.3 grams (0.052 mole) of 2-(3,5-difluorophenyl)ethanol and 8.9 grams (0.130 mole) of imidazole in about 100 mL of methylene chloride was stirred, and a solution of 13.9 mL (0.065 mole) of triisopropylsilyl chloride in about 25 mL of methylene chloride was added dropwise. Upon completion of addition, the reaction mixture stirred at ambient temperature for about 18 hours. After this time the reaction mixture was diluted with about 200 mL of water, the organic layer was separated, and the aqueous layer was extracted with one 150 mL portion of methylene chloride. The methylene chloride extract was combined with the organic layer, and filtering it through a silicone-coated filter paper dried the combination. The filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using mixtures of methylene chloride and petroleum ether. The fractions containing product were combined and concentrated under reduced pressure, yielding 15.8 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step C Synthesis of 2,6-difluoro-4-[2-[tri(1-methylethyl)silyloxy]ethyl]benzaldehyde as an Intermediate

A stirred solution of 3.0 grams (0.0095 mole) of tri(1-methylethyl)silyl 2-(3,5-difluorophenyl)ethyl ether in 50 mL of THF was cooled to about −78° C., and 4.0 mL of 2.5M solution of n-butyllithium (0.0100 mole-in hexane) was added dropwise during a 15 minute period while maintaining the reaction mixture temperature at about −75° C. Upon completion of addition, the cold reaction mixture was stirred for about 30 minutes and a solution of 1.4 grams (0.0190 mole) of DMF in 25 mL of THF was added dropwise. Upon completion of addition, stirring of the reaction mixture was continued at about −75° C. for 1.5 hours. The reaction mixture was then treated with a dilute aqueous ammonium chloride solution, and extracted with two 200 mL portions of diethyl ether. The combined extracts were washed with one 75 mL portion of aqueous 10% lithium chloride, dried with magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using mixtures of methylene chloride and petroleum ether. The fractions containing product were combined and concentrated under reduced pressure, yielding 1.6 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step D Synthesis of tri(1-methylethyl)silyl 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethyl ether as an Intermediate

A solution of 1.2 grams (0.0035 mole) of 2,6-difluoro-4-[2-[tri(1-methylethyl)silyloxy]ethyl]benzaldehyde and 0.56 gram (0.0058 mole) of O-ethylhydroxylamine hydrochloride in 30 mL of acetonitrile was stirred, and 0.59 gram (0.0058 mole) of triethylamine was added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for about 18 hours. After this time, the reaction mixture was diluted with about 70 mL of water and extracted with two 75 mL portions of ethyl acetate. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using mixtures of methylene chloride and petroleum ether. The fractions containing product were combined and concentrated under reduced pressure, yielding 1.2 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step E Synthesis of 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethanol as an Intermediate

A solution of 0.95 gram (0.0025 mole) of tri(1-methylethyl)silyl 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethyl ether in 25 mL of THF was stirred, and 3.7 mL (0.0037 mole) of 1M of tetrabutylammonium fluoride (in THF) was added in one portion. Upon completion of addition, the reaction mixture was stirred for about two hours. After this time, the reaction mixture was diluted with water and extracted with two 75 mL portions of ethyl acetate. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on neutral alumina using mixtures of diethyl ether and petroleum ether. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.55 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step F Synthesis of Compound 1323

This compound was prepared in accordance with the method of Example 1, Step B, using 0.32 gram (0.0022 mole) of 1-hydroxy-2-methylbenzimidazole, 0.3 gram (0.0013 mole) of 2-[3,5-difluoro-4-(ethoxyiminomethyl)phenyl]ethanol, 0.58 gram (0.0022 mole) of triphenylphosphine, and 0.38 gram (0.0022 mole) of DEAD in 15 mL of THF. The product was purified by column chromatography on neutral alumina using methylene chloride. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.34 gram of Compound 1323, mp 70-72° C. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 10 This Example Illustrates One Protocol for the Preparation of propyl 2-chloro-4-[2-(2-methylbenzimidazol-1-ylamino)ethyl]benzoate (Compound 302 in Table Below) Step A Synthesis of 2-[(4-bromo-3-chlorophenyl)methyl]-1,3-dioxolane as an Intermediate

A stirred solution of 27.9 grams (0.199 mole) of 4-bromo-3-chlorophenylacetaldehyde (known compound), 8.5 grams (0.137 mole) of 1,2-ethanediol, and an catalytic amount of p-toluenesulfonic acid in 300 mL of hexane was heated at reflux for about three hours. After this time the reaction mixture was allowed to cool to ambient temperature as it stood for about 18 hours. The heterogeneous reaction mixture was then stirred with a small amount of diethyl ether to dissolve an oil, and the solution was washed in turn with one portion of aqueous 5% potassium carbonate solution, one portion of water, and one portion of an aqueous solution saturated with sodium chloride. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residual oil. The oil was purified by column chromatography on silica gel using mixtures of hexane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 16.0 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of lithium 2-chloro-4-(1,3-dioxolan-1-ylmethyl)benzoate as an Intermediate

A stirred solution of 5.0 mL (0.0079 mole) of 1.6M n-butyllithium (in hexanes) in 40 mL of THF was cooled to −60° C., and a solution of 2.0 grams (0.0072 mole) of 2-[(4-bromo-3-chlorophenyl)methyl]-1,3-dioxolane in 10 mL of THF was added at a rate to maintain the reaction mixture temperature below −60° C. Upon completion of addition, the reaction mixture stirred for about 20 minutes, then an excess of carbon dioxide (from dry ice) was bubbled into the reaction mixture. The exothermic reaction caused the reaction mixture temperature to rise to about 40° C. Upon completion of addition the reaction mixture stirred for about 45 minutes, then it was poured into 200 mL of hexane. The resultant solid was collected by filtration and washed in turn with two portions of 20% diethyl ether in hexane and one portion of hexane. The solid was dried, yielding 1.5 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step C Synthesis of propyl 2-chloro-4-(1,3-dioxolan-1-ylmethyl)benzoate as an Intermediate

A solution of 1.1 grams (0.0044 mole) of lithium 2-chloro-4-(1,3-dioxolan-1-ylmethyl)benzoate and 1.1 grams (0.0088 mole) of n-propyl bromide in 20 mL of DMF was warmed to 60° C. where it stirred for about 18 hours. After this time the reaction mixture was placed in a separatory funnel with water. The mixture was extracted with two portions of ethyl acetate, and the combined extracts were washed in turn with one portion of water and one portion of an aqueous solution saturated with sodium chloride. The organic layer was dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure, yielding 0.52 gram of residue.

In an effort to isolate additional material, the water layer above and all of the water washes were combined and saturated with sodium chloride. The mixture was extracted with two portions of ethyl acetate, and the combined extracts were washed with one portion of an aqueous solution saturated with sodium chloride. The organic layer was dried with sodium sulfate and filtered. The filtrate was combined with the 0.52 gram of residue above, and the mixture was concentrated under reduced pressure, yielding 0.90 gram of residue. The residue was purified by column chromatography on silica gel using mixtures of hexane and ethyl acetate. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.76 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step D Synthesis of propyl 2-chloro-4-formylmethylbenzoate as an Intermediate

A stirred solution of 0.65 gram (0.0023 mole) of propyl 2-chloro-4-(1,3-dioxolan-1-ylmethyl)benzoate and 15 mL of aqueous 2N hydrochloric acid in 15 mL of THF was heated at reflux for about seven hours. After this time the reaction mixture was allowed to cool to ambient temperature while it stood for about 18 hours. The reaction mixture was placed in a separatory funnel with an aqueous solution saturated with sodium chloride, and the mixture was extracted with ethyl acetate. The combined extracts were concentrated under reduced pressure, yielding 0.62 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step E Synthesis of Compound 302

This compound was prepared in accordance with the method of Example 3, Step B, using 0.62 gram (0.0023 mole) of propyl 2-chloro-4-formylmethylbenzoate, 0.40 gram (0.027 mole) of 1-amino-2-methylbenzimidazole, 0.13 gram (0.0007 mole) of p-toluenesulfonic acid, 0.29 gram (0.0046 mole) of sodium cyanoborohydride, 1 mL of ethanolic hydrochloric acid, and 10 mL of ethanol in toluene. The product was purified by column chromatography on silica gel using mixtures of ethyl acetate and hexane. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.35 gram of Compound 302. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 11 This Example Illustrates One Protocol for the Preparation of 1-[2-[4-(1-propylbutoxy)phenyl]ethoxy]-2,4-dimethylbenzimidazole (Compound 413 in Table Below) Step A Synthesis of 1-[2-(4-methoxyphenyl)ethoxy]-2,4-dimethylbenzimidazole as an Intermediate

This compound was prepared in accordance with the method of Example 1, Step B, using 1.8 grams (0.0111 mole) of 1-hydroxy-2,4-dimethylbenzimidazole, 1.5 grams (0.0099 mole) of 2-(4-methoxyphenyl)ethanol, 2.9 grams (0.0111 mole) of triphenylphosphine, and 1.8 mL (0.0144 mole) of DEAD in 20 mL of THF. The yield of the subject compound was 1.4 grams. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of 1-[2-(4-hydroxyphenyl)ethoxy]-2,4-dimethylbenzimidazole as an Intermediate

A stirred solution of 1.4 grams (0.0049 mole) of 1-[2-(4-methoxyphenyl)ethoxy]-2,4-dimethylbenzimidazole in 200 mL of chloroform was cooled to about −60° C., and 15 mL of a 1M solution (in methylene chloride) of boron tribromide was added slowly. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature as it stirred for about 18 hours. After this time the reaction mixture was slowly poured into 600 mL of an aqueous solution saturated with sodium bicarbonate. The mixture was stirred for about two hours, and then it was extracted with two 200 mL portions of ethyl acetate. The combined extracts were washed with one portion of an aqueous solution saturated with sodium chloride, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, yielding 1.2 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step C Synthesis of Compound 413

This compound was prepared in accordance with the method of Example 1, Step B, using 0.33 gram (0.0012 mole) of 1-[2-(4-hydroxyphenyl)ethoxy]-2,4-dimethylbenzimidazole, 0.16 gram (0.0014 mole) of 4-heptanol, 0.37 gram (0.0014 mole) of triphenylphosphine, and 0.23 mL (0.0015 mole) of DEAD in 10 mL of THF. The product was purified by column chromatography on silica gel using mixtures of ethyl acetate and hexane. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.11 gram of Compound 416. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 12 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethoxy]-2-methyl-4,5,6,7-tetrahydrobenzimidazole (Compound 244 in Table Below) Step A Synthesis of 1-hydroxy-2-methyl-4,5,6,7-tetrahydrobenzimidazole as an Intermediate

A solution of 1.35 gram (0.0106 mole) of 1,2-cyclohexanone monoxime (known compound) and 0.6 mL (0.0107 mole) of acetaldehyde in 8 mL of ethanol was stirred, and 1.4 mL (excess) of ammonium hydroxide was added in one portion. The resultant exothermic reaction caused the reaction mixture temperature to rise to about 30-40° C. The reaction mixture was then stirred as it cooled to ambient temperature, and then it was concentrated under reduced pressure to a residue, yielding 1.6 grams of crude (25-50% pure) subject compound. The subject compound was used without further purification.

Step B Synthesis of Compound 244

This compound was prepared in accordance with the method of Example 1, Step B, using 1.60 grams (0.0053 mole) of 1-hydroxy-2-methyl-4,5,6,7-tetrahydrobenzimidazole (25-50% pure), 0.60 gram (0.0026 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol, 1.40 grams (0.0053 mole) of triphenylphosphine, and 0.88 gram (0.0051 mole) of DEAD in about 15 mL of THF. The product was purified by column chromatography on silica gel using mixtures of methylene chloride and methanol. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.50 gram of Compound 244 that was about 90% pure. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 13 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethoxy]-2,4,5-trimethylimidazole (Compound 9 in Table Below)

This compound was prepared in accordance with the method of Example 1, Step B, using 0.30 gram (0.0024 mole) of 1-hydroxy-2,4,5-trimethylimidazole (known compound), 0.50 gram (0.0022 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol, 0.65 gram (0.0025 mole) of triphenylphosphine, and 0.40 gram (0.0025 mole) of DEAD in 10 mL of THF. Compound 9 was isolated without further purification in greater than 90% purity, yielding 0.65 gram of product. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 14 This Example Illustrates One Protocol for the Preparation of 1-[[2-methyl-2-(4-n-butoxyphenyl)propyl]amino]-2-methylbenzimidazole (Compound 305 in table below) and 1-[[2-methyl-2-(4-n-butoxyphenyl)propyl]imino]-2-methylbenzimidazole (Compound 384 in Table Below) Step A Synthesis of 2-methyl-2-(4-n-butoxyphenyl)propionaldehyde as an Intermediate

Under a nitrogen atmosphere, a stirred solution of 1.4 grams (0.0064 mole) of 2-methyl-2-(4-n-butoxyphenyl)propionitrile (known compound) in 25 mL of toluene was cooled to about 45° C. and 10 mL of 1 Molar (in toluene) diisobutylaluminum hydride was added dropwise at a rate to maintain the reaction mixture temperature below about −40° C. Upon completion of addition, the reaction mixture was warmed to about −5° C. where it stirred for about one hour. After this time, 10 mL of an aqueous solution of 2N sulfuric acid was added slowly. Upon completion of addition, the reaction mixture was stirred for an additional one hour. The reaction mixture was then poured into 50 mL of water and extracted with two 20 mL portions of ethyl acetate. The combined extracts were washed with an aqueous solution saturated with sodium chloride, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, yielding 1.2 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of Compounds 305 and 384

These compounds were prepared in accordance with the method of Example 3, Step B, using about 0.75 gram (0.0051 mole) of 2-methyl-2-(4-n-butoxyphenyl)propionaldehyde, 1.3 grams (0.0059 mole) of 1-amino-2-methylbenzimidazole, 0.5 mL (0.0087 mole) of acetic acid, and 0.60 gram (0.0096 mole) of sodium cyanoborohydride in 50 mL of ethanol. The products were purified and separated by column chromatography on silica gel using mixtures of ethyl acetate and heptane. The appropriate fractions containing each product were combined and concentrated under reduced pressure, yielding 0.38 gram of Compound 305, and 0.28 gram of Compound 384. The NMR spectra were consistent with the proposed structures.

EXAMPLE 15 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethylamino]-1,3-dihydro-3-methyl-2H-benzimidazol-2-one (Compound 417 in Table Below)

This compound was prepared in accordance with the method of Example 3, Step B, using 0.30 gram (0.0013 mole) of 3-chloro-4-n-butoxyphenylacetaldehyde, about 0.34 gram (0.0021 mole) of 1-amino-1,3-dihydro-3-methyl-2H-benzimidazol-2-one (known compound), 2 mL of acetic acid, and 0.13 gram (0.0020 mole) of sodium cyanoborohydride in 20 mL of ethanol. The product was purified by column chromatography on alumina using methylene chloride and mixtures of methylene chloride and methanol. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.18 gram of Compound 417. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 16 This Example Illustrates One Protocol for the Preparation of 1-[2-(3-chloro-4-n-butoxyphenyl)ethoxy]-1H-benzotriazole (Compound 285 in Table Below)

This compound was prepared in accordance with the method of Example 1, Step B, using 0.30 gram (0.0022 mole) of 1-hydroxy-1H-benzotriazole hydrate, 0.35 gram (0.0015 mole) of 2-(3-chloro-4-n-butoxyphenyl)ethanol, 1.20 gram (0.0046 mole) of triphenylphosphine, 0.75 gram (0.0048 mole) of DEAD, and a small quantity of molecular sieves in about 10 mL of THF. The product was purified by column chromatography on silica gel using methylene chloride. The fractions containing product were combined and concentrated under reduced pressure, yielding about 0.20 gram of Compound 285. The NMR spectrum was consistent with the proposed structure.

EXAMPLE 17 This Example Illustrates One Protocol for the Preparation of 1-(7-Butoxy-3,7-dimethyl-oct-2-enyl)-2-chloro-1H-benzoimidazole (Compound 1343 in Table Below) Step A Synthesis of 2-Chloro-1-(3,7-dimethyl-octa-2,6-dienyl)-1H-benzoimidazole as an Intermediate

A stirred solution of 1.6 grams (0.040 mole) of sodium hydride in 50 mL of DMF was cooled to about 5° C., and 5.45 grams (0.036 mole) of 2-Chlorobenzimidazole in 5 ml DMF was added dropwise, while maintaining the reaction mixture temperature between about 5° C. and about 10° C. Upon completion of addition, the reaction mixture was stirred as it warmed to ambient temperature. After this time the reaction mixture was added to 100 mL of water. The mixture was extracted with 100 mL of ethyl acetate, and the extract was rinsed twice with 200 ml water and once with 100 ml saturated sodium chloride solution then dried with magnesium sulfate. The mixture was filtered and the filtrate was concentrated under reduced pressure to a residue, yielding 9.4 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Step B Synthesis of Compound 1343

A suspension of 1.82 grams (0.0057 mole) of mercuric acetate in about 50 mL of n-butanol was vigorously stirred, and 1.5 grams (0.0052 mole) of 2-Chloro-1-(3,7-dimethyl-octa-2,6-dienyl)-1H-benzoimidazole was added in one portion. Upon completion of addition, the reaction mixture stirred at ambient temperature for about 18 hours. After this time the reaction mixture was cooled while maintaining the reaction mixture temperature between about 5° C. and about 10° C., 10 ml of 3M sodium hydroxide was added followed by 25 ml 0.5M sodium borohydride (in a solution of 3M sodium hydroxide). Upon completion of addition, the reaction mixture was stirred as it warmed to ambient temperature. The reaction mixture was added to 100 ml water. The mixture was extracted with 100 mL of heptane, and the extract was rinsed with 100 ml 3M sodium hydroxide, 100 ml water and with 100 ml saturated sodium chloride solution then dried with magnesium sulfate. The mixture was filtered and the filtrate was concentrated under reduced pressure to a residue. The residue was purified by column chromatography on silica gel using methylene chloride. The fractions containing product were combined and concentrated under reduced pressure, yielding 0.82 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

It is well known to one of ordinary skill in the art that the compounds of formula (I) of the present invention can contain optically active and racemic forms. It is also well known in the art that the compounds of formula (I) may contain stereoisomeric forms and/or exhibit polymorphism. It is to be understood that the present invention encompasses any racemic, optically-active, polymorphic, or stereoisomeric form, or mixtures thereof. It should be noted that it is well known in the art how to prepare optically active forms, for example by resolution of a racemic mixture, or by synthesis from optically-active intermediates.

The following table sets forth additional compounds of the present invention, where Y is selected from the following:

where R⁴ is, inter alia, selected from the following:

TABLE 1 (I)

Cmpd No. M/Q/R R¹ R² W R³ X Y R⁴ 1 C/C/CH₃ H H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2 C/C/CH₃ H Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 3 C/C/CH₃ Cl H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 4 C/C/CH₃ Cl Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 5 C/C/CH₃ H CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 6 C/C/CH₃ CH₃ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 7 C/C/CH₃ CH₃ Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 8 C/C/CH₃ Cl CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 9 C/C/CH₃ CH₃ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 10 C/C/CH₃ H OCH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 11 C/C/CH₃ OCH₃ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 12 C/C/CH₃ OCH₃ Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 13 C/C/CH₃ Cl OCH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 14 C/C/CH₃ OCH₃ OCH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 15 C/C/CH₃ CH₃ C₂H₅ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 16 C/C/CH₃ C₂H₅ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 17 C/C/CH₃ CF₃ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 18 C/C/CH₃ H CF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 19 C/C/CH₃ CF₃ Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 20 C/C/CH₃ Cl CF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 21 C/C/CH₃ CF₃ CF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 22 C/C/CH₃ CF₃ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 23 C/C/CH₃ CH₃ CF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 24 C/C/CH₃ OCF₃ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 25 C/C/CH₃ H OCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 26 C/C/CH₃ OCF₃ Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 27 C/C/CH₃ Cl OCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 28 C/C/CH₃ OCF₃ OCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 29 C/C/CH₃ OCF₃ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 30 C/C/CH₃ CH₃ OCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 31 C/C/CH₃ SCF₃ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 32 C/C/CH₃ H SCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 33 C/C/CH₃ SCF₃ Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 34 C/C/CH₃ Cl SCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 35 C/C/CH₃ SCF₃ SCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 36 C/C/CH₃ S(O)CF₃ S(O)CF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 37 C/C/CH₃ S(O)₂CF₃ S(O)₂CF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 38 C/C/CH₃ SCF₃ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 39 C/C/CH₃ CH₃ SCF₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 40 C/C/CH₃ NH₂ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 41 C/C/CH₃ H NH₂ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 42 C/C/CH₃ NH₂ NH₂ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 43 C/C/CH₃ NHCH₃ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 44 C/C/CH₃ H NHCH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 45 C/C/CH₃ NHCH₃ NHCH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 46 C/C/CH₃ NHCH₃ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 47 C/C/CH₃ CH₃ NHCH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 48 C/C/CH₃ H N(CH₃)₂ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 49 C/C/CH₃ N(CH₃)₂ H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 50 C/C/CH₃ N(CH₃)₂ N(CH₃)₂ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 51 C/C/CH₃ N(CH₃)₂ CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 52 C/C/CH₃ CH₃ N(CH₃)₂ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 53 C/C/CH₃ phenyl H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 54 C/C/CH₃ H phenyl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 55 C/C/CH₃ phenyl Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 56 C/C/CH₃ Cl phenyl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 57 C/C/CH₃ phenyl CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 58 C/C/CH₃ CH₃ phenyl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 59 C/C/CH₃ H 4-Clphenyl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 60 C/C/CH₃ 4-Clphenyl Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 61 C/C/CH₃ Cl 4-Clphenyl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 62 C/C/CH₃ 4-Clphenyl CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 63 C/C/CH₃ CH₃ 4-Clphenyl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 64 C/C/CH₃ pyrid-2-yl H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 65 C/C/CH₃ H pyrid-2-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 66 C/C/CH₃ pyrid-2-yl Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 67 C/C/CH₃ Cl pyrid-2-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 68 C/C/CH₃ pyrid-2-yl CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 69 C/C/CH₃ CH₃ pyrid-2-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 70 C/C/CH₃ pyrid-3-yl H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 71 C/C/CH₃ H pyrid-3-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 72 C/C/CH₃ pyrid-3-yl Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 73 C/C/CH₃ Cl pyrid-3-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 74 C/C/CH₃ pyrid-3-yl CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 75 C/C/CH₃ CH₃ pyrid-3-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 76 C/C/CH₃ pyrid-4-yl H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 77 C/C/CH₃ H pyrid-4-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 78 C/C/CH₃ pyrid-4-yl Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 79 C/C/CH₃ Cl pyrid-4-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 80 C/C/CH₃ pyrid-4-yl CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 81 C/C/CH₃ CH₃ pyrid-4-yl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 82 C/C/CH₃ 6-Clpyrid- H O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 83 C/C/CH₃ H 6-Clpyrid- O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 84 C/C/CH₃ 6-Clpyrid- Cl O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 85 C/C/CH₃ Cl 6-Clpyrid- O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 86 C/C/CH₃ 6-Clpyrid CH₃ O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 87 C/C/CH₃ CH₃ 6-Clpyrid- O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 88 N/C/CH₃ — H NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 89 N/C/CH₃ — Cl NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 90 N/C/CH₃ — CH₃ NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 91 N/C/CH₃ — OCH₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 92 N/C/CH₃ — CF₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 93 N/C/CH₃ — OCF₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 94 N/C/CH₃ — SCF₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 95 N/C/CH₃ — S(O)CF₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 96 N/C/CH₃ — S(O)₂CF₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 97 N/C/CH₃ — NH₂ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 98 N/C/CH₃ — NHCH₃ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 99 N/C/CH₃ — N(CH₃)₂ NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 100 N/C/CH₃ — phenyl NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 101 N/C/CH₃ — 4-Clphenyl NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 102 N/C/CH₃ — pyrid-2-yl NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 103 N/C/CH₃ — pyrid-3-yl NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 104 N/C/CH₃ — pyrid-4-yl NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 105 N/C/CH₃ — 6-Clpyrid- NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 106 N/C/CH₃ — H N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 107 N/C/CH₃ — Cl N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 108 N/C/CH₃ — CH₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 109 N/C/CH₃ — OCH₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 110 N/C/CH₃ — CF₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 111 N/C/CH₃ — OCF₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 112 N/C/CH₃ — SCF₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 113 N/C/CH₃ — S(O)CF₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 114 N/C/CH₃ — S(O)₂CF₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 115 N/C/CH₃ — NH₂ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 116 N/C/CH₃ — NHCH₃ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 117 N/C/CH₃ — N(CH₃)₂ N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 118 N/C/CH₃ — phenyl N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 119 N/C/CH₃ — 4-Clphenyl N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 120 N/C/CH₃ — pyrid-2-yl N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 121 N/C/CH₃ — pyrid-3-yl N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 122 N/C/CH₃ — pyrid-4-yl N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 123 N/C/CH₃ — 6-Clpyrid- N═ — —CHCH₂— A1 3-Cl, 4-n-OC₄H₉ 2-yl 124 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 H 125 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-Br 126 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl 127 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2,4-diCl₂ 128 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-F 129 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-I 130 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 2-F 131 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-CH₃ 132 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-C₂H₅ 133 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-n-C₄H₉ 134 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-n-C₅H₁₁ 135 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-C(CH₃)₃ 136 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-(cyclohexyloxymethyl) 137 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-NH₂ 138 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-NHCH₃ 139 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-N(CH₃)₂ 140 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-NHSO₂CH₃ 141 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-OH 142 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-OCH₃ 143 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3,5-di(OCH₃)₂ 144 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-n-OC₃H₇ 145 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-n-OC₄H₉ 146 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-n-S(O)C₄H₉ 147 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-OCF₃ 148 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-C(O)-n-C₄H₉ 149 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-CO₂-n-C₃H₇ 150 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-P(O)(OC₂H₅)₂ 151 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-OCH₃, 5-Cl 152 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-OC₂H₅ 153 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂O— A1 3-Cl, 4-n-OC₃H₇ 154 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-Cl, 4-n-OC₄H₉ 155 C/C/CH₃ —CH═CHCH═CH— O — —CH₂— A1 3-Cl, 4-n-OC₄H₉ 156 C/C/H —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 157 C/C/Cl —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 158 C/C/F —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 159 C/C/OH —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 160 C/C/CH₂F —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 161 C/C/CHF₂ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 162 C/C/CN —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 163 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 164 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-SC₄H₉ 165 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 166 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-cyclopropylCH₂O 167 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₅H₁₁ 168 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-cyclohexyloxy 169 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-cyclohexyloxy 170 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-heptyloxy 171 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-(1,4-dioxapentyl) 172 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-(1,4,7-trioxaoctyl) 173 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl; 4-OCH₂CH₂CF₃ 174 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl; 4-OC₂H₄Si(CH₃)₃ 175 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-NHC₄H₉ 176 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-N(CH₃)C₄H₉ 177 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-(4-CF₃OPh) 178 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-(4-ClPhCH₂O) 179 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-I, 4-n-OC₄H₉ 180 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-CH₃, 4-OCH₃ 181 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-CH₃, 4-n-OC₄H₉ 182 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2,3-di(CH₃)₂, 4-n-OC₄H₉ 183 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-CH(CH₃)₂, 4-n-OC₄H₉ 184 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-CF₃, 4-n-OC₄H₉ 185 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-CN, 4-n-OC₄H₉ 186 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-NO₂, 4-n-OC₄H₉ 187 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-NH₂, 4-n-OC₄H₉ 188 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-OCH₃, 4-n-OC₄H₉ 189 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-B1 190 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-B2 191 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-B3 192 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-phenyl 193 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-phenyl 194 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-CH₃, 4-phenyl 195 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-(thien-3-yl) 196 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-Cl, 6-(thien-2-yl) 197 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-(4-nitrophenoxy) 198 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-phenylmethoxy 199 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2,4-bis(phenylmethoxy) 200 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-Cl, 4-NO₂, 6-F 201 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-phenyl., 4-n-OC₄H₉ 202 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-NO₂, 4-(2-Cl-4-CF₃Ph) 203 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2,3,5,6-F₄, 4-n-OC₄H₉ 204 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂CH₂— A1 4-C(CH₃)₃ 205 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH═C(CH₃)— A1 3-Cl, 4-n-OC₄H₉ 206 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 1-naphthyl 207 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 2-naphthyl 208 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A2 2-C₄H₉ 209 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A3 2,2-H₂ 210 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A4 6-Cl 211 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A4 6-n-OC₄H₉ 212 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂CH₂— A4 H 213 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂CH₂— A5 H 214 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A6 5-n-OC₄H₉ 215 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A7 2-n-OC₅H₁₁ 216 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A7 6-n-OC₅H₁₁ 217 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A8 2-n-OC₄H₉ 218 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A9 6-n-OC₄H₉ 219 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A10 3-n-OC₅H₁₁ 220 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A11 5-n-OC₄H₉ 221 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A12 2-n-OC₄H₉ 222 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A13 5-n-OC₄H₉ 223 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A13 4-n-OC₄H₉ 224 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A14 2-n-OC₄H₉ 225 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A15 4-n-OC₅H₁₁ 226 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A15 5-n-OC₄H₉ 227 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A16 4-n-OC₄H₉ 228 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A16 5-n-OC₄H₉ 229 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A17 2-n-OC₄H₉ 230 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A18 5-n-OC₄H₉ 231 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A18 4-n-OC₅H₁₁ 232 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A19 5-n-OC₅H₁₁ 233 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A20 4-n-OC₅H₁₁ 234 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A21 5-n-OC₄H₉ 235 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A22 2-C₂H₅ 236 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A22 2-n-OC₄H₉ 237 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A23 3-n-OC₅H₁₁ 238 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A24 2-n-OC₅H₁₁ 239 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A25 3-n-OC₄H₉ 240 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A25 4-n-OC₄H₉ 241 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A26 2-n-OC₅H₁₁ 242 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A27 4-n-OC₄H₉ 243 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A28 4-n-OC₄H₉ 244 C/C/CH₃ —C₄H₈— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 245 C/C/CH₃ —C(Cl)═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 246 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 247 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— A1 3,5-Cl₂, 4-n-OC₄H₉ 248 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— A1 2,3-(CH₃)₂, 4-n-OC₄H₉ 249 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 250 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 251 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— A1 3,5-Cl₂, 4-n-OC₄H₉ 252 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 253 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 254 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— A1 3,5-Cl₂, 4-n-OC₄H₉ 255 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 256 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 257 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— A1 3,5-Cl₂, 4-n-OC₄H₉ 258 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 259 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 260 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— A1 3,5-Cl₂, 4-n-OC₄H₉ 261 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 262 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A29 — 263 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 4-OCH(CH₃)₂ 264 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 4-OC₂H₄OCH₃ 265 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 4-OCO₂C₂H₅ 266 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 267 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ HCl salt 268 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 4-Cl, 3-n-OC₄H₉ 269 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 3-F, 4-n-OC₄H₉ 270 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— A1 2,3-(CH₃)₂, 4-n-OC₄H₉ 271 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH(CH₃)— A30 6-OCH₃ 272 C/C/CH₃ —CH═C(CH₃)CH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 273 C/C/CH₃ —CH═CHC(CH₃)═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 274 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 275 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 276 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 277 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 278 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 279 C/C/CH₃ —C(OCH₃)═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 280 C/C/CH₃ —C(CN)═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 281 C/C/CH₃ —C(CN)═CHCH═CH— O — —CH₂CH₂— A1 3,5-Cl₂, 4-n-OC₄H₉ 282 C/C/CH₃ —C(CN)═CHCH═CH— O — —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 283 C/C/CH₃ —C(C≡CH)═CHCH═CH— O — —CH₂CH₂— 3-Cl, 4-n-OC₄H₉ 284 C/C/CH₃ —N═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 285 C/N/— —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 286 C/C/CH₃ —CH═CHCH═CH— S(O)₂ — —CH₂— A1 4-n-OC₄H₉ 287 C/C/CH₃ —CH═CHCH═CH— S(O)₂ — —CH₂CH₂— A1 4-n-OC₄H₉ 288 C/C/CH₃ —CH═CHCH═CH— S(O)₂ — —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 289 C/C/CH₃ —C(F)═CHCH═CH— S(O)₂ — —CH₂CH₂— A1 4-n-OC₄H₉ 290 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-C(CH₃)₃ 291 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-C₅H₁₁ 292 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-C(O)C₄H₉ 293 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH(CH₃)CH₂— A1 4-C(CH₃)₃ 294 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-OCH₃ 295 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-OC₄H₉ 296 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-SC₄H₉ 297 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-SC₄H₉ 298 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-S(O)C₄H₉ 299 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-S(O)₂C₄H₉ 300 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-CO₂C₂H₅ 301 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-CO₂C₃H₇ 302 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-CO₂C₃H₇ 303 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-CO₂C₄H₉ 304 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-P(O)(OC₂H₅)₂ 305 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂C(CH₃)₂— A1 4-n-OC₄H₉ 306 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂— A1 3-Cl, 4-n-OC₄H₉ 307 C/C/H —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 308 C/C/Cl —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 309 C/C/F —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 310 C/C/OH —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 311 C/C/CH₂F —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 312 C/C/CHF₂ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 313 C/C/CN —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 314 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 315 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH(CH₃)CH₂— A1 3-Cl, 4-n-OC₄H₉ 316 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH[CH(CH₃)₂]— A1 3-Cl, 4-n-OC₄H₉ 317 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂C(CH₃)₂— A1 3-Cl, 4-n-OC₄H₉ 318 C/C/CH₃ —CH═CHCH═CH— NR³ C(O)CH₃ —CH₂CH₂— A1 3,5-diCl, 4-n-OC₄H₉ 319 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 2,3-(CH₃)₂, 4-n-OC₄H₉ 320 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 321 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A31 2-CH₃, 2-n-C₃H₇ 322 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A3 2-CH₃, 2-n-C₃H₇ 323 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 324 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 325 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— A1 2,3-(CH₃)₂, 4-n-OC₄H₉ 326 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 327 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 328 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 329 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 330 C/C/CH₃ —CH═CHCH═C(F)— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 331 C/C/CH₃ —CH═CHCH═C(F)— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 332 C/C/CH₃ —CH═CHCH═C(F)— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 333 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 334 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 335 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 336 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 337 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 338 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 339 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 340 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 341 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 342 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— A1 4-OC₂H₄OCH₃ 343 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 344 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— A1 2,3-(CH₃)₂, 4-n-OC₄H₉ 345 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 346 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉ 347 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 348 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— A1 3,5-(CH₃)₂, 4-n-OC₄H₉ 349 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A4 6-Cl 350 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A4 6-n-OC₄H₉ 351 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂CH₂— A4 H 352 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂CH₂— A5 H 353 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A6 5-n-OC₄H₉ 354 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A7 2-n-OC₅H₁₁ 355 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A7 6-n-OC₅H₁₁ 356 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A8 2-n-OC₄H₉ 357 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A9 6-n-OC₄H₉ 358 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A10 3-n-OC₅H₁₁ 359 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A11 5-n-OC₄H₉ 360 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A12 2-n-OC₄H₉ 361 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A13 5-n-OC₄H₉ 362 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A13 4-n-OC₄H₉ 363 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A14 2-n-OC₄H₉ 364 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A15 4-n-OC₅H₁₁ 365 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A15 5-n-OC₄H₉ 366 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A16 4-n-OC₄H₉ 367 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A16 5-n-OC₄H₉ 368 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A17 2-n-OC₄H₉ 369 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A18 5-n-OC₄H₉ 370 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A18 4-n-OC₅H₁₁ 371 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A19 5-n-OC₅H₁₁ 372 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A20 4-n-OC₅H₁₁ 373 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A21 5-n-OC₄H₉ 374 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A22 2-C₂H₅ 375 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A22 2-n-OC₄H₉ 376 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A23 3-n-OC₅H₁₁ 377 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A24 2-n-OC₅H₁₁ 378 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A25 3-n-OC₄H₉ 379 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A25 4-n-OC₄H₉ 380 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A26 2-n-OC₅H₁₁ 381 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A27 4-n-OC₄H₉ 382 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A28 4-n-OC₄H₉ 383 C/C/CH₃ —CH═CHCH═CH— —N═ — —CHCH₂— A1 4-C(CH₃)₃ 384 C/C/CH₃ —CH═CHCH═CH— —N═ — —CHC(CH₃)₂— A1 4-n-OC₄H₉ 385 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂Br 386 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂CH₂Br 387 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂CH₂OH 388 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂C≡N 389 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂NC₂H₅ 390 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₃NHC(═NH)NH₂ 391 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂NC(═O)Ph 392 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂N═CHPh 393 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂-cyclo-C₃H₇ 394 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂(2,3,4,5,6-F₅Ph) 395 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂Ph 396 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂OPh 397 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂S(O)₂Ph 398 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂CH₂OH 399 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂CH₂Cl 400 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-OCH₂CH₂CH₂O-B4 401 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-NH₂, 5-Cl, 4-n-OC₄H₉ 402 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A32 2-n-C₃H₇, 7-Cl 403 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3,5-diCl₂, 4-n-OC₄H₉ 404 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-O(CH₂)₄F 405 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-O(CH₂)₃CF₃ 406 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂— A33 6-n-OC₄H₉ 407 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A34 4-n-C₅H₁₁ 408 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-CO₂H 409 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-CO₂H 410 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-CO₂H 411 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3-Cl, 4-CO₂H 412 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 3,5-F₂, 4-CH₂OC₃H₇ 413 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— A1 4-OCH(C₃H₇)₂ where M/Q are C/C═O Cmpd 3-Position N- No. Substituent R¹ R² W R³ X Y R⁴ 414 H —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 H 415 H —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-CH₃ 416 CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 4-n-OC₄H₉ 417 CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— A1 3-Cl, 4-n-OC₄H₉

(I)

where M/Q/R are C/C/CH₃, Y is Al, X is —(CH₂)_(m)—U(R⁵)_(p)—(CH₂)_(m) ¹—, and R⁴ is 3-Cl, 4-n-OC₄H₉ Cmpd No. R¹ R² W R³ m U R⁵ p q r m¹ 418 H H O — 1 CH OH 1 — — 1 419 H H O — 1 CH OCH₃ 1 — — 0 420 H H O — 1 C —C₂H₄— 1 — — 1 421 H H O — 1 C —C₂H₄— 1 — — 2 422 H H O — 1 C —C₄H₉— 1 — — 1 423 H H O — 2 Si CH₃ 2 — — 0 424 H H O — 0 S(O)_(r) — 0 — 0 1 425 H H O — 1 S(O)_(r) — 0 — 0 0 426 H H O — 0 S(O)_(r) — 0 — 2 1 427 H H O — 1 S(O)_(r) — 0 — 2 0 428 H H O — 1 N(═O)_(q) CH₃ 1 0 — 0 429 H H O — 1 N(═O)_(q) CH₃ 1 1 — 0 430 H H O — 0 C═O — 0 — — 0 431 H H O — 0 C═O — 0 — — 1 432 H H O — 1 C═O — 0 — — 0 433 H Cl O — 1 CH OH 1 — — 1 434 H Cl O — 1 CH OCH₃ 1 — — 0 435 H Cl O — 1 C —C₂H₄— 1 — — 1 436 H Cl O — 1 C —C₂H₄— 1 — — 2 437 H Cl O — 1 C —C₄H₈— 1 — — 1 438 H Cl O — 2 Si CH₃ 2 — — 0 439 H Cl O — 0 S(O)_(r) — 0 — 0 1 440 H Cl O — 1 S(O)_(r) — 0 — 0 0 441 H Cl O — 0 S(O)_(r) — 0 — 2 1 442 H Cl O — 1 S(O)_(r) — 0 — 2 0 443 H Cl O — 1 N(═O)_(q) CH₃ 1 0 — 0 444 H Cl O — 1 N(═O)_(q) CH₃ 1 1 — 0 445 H Cl O — 0 C═O — 0 — — 0 446 H Cl O 0 C═O — 0 — — 1 447 H Cl O 1 C═O — 0 — — 0 448 Cl H O — 1 CH OH 1 — — 1 449 Cl H O — 1 CH OCH₃ 1 — — 0 450 Cl H O — 1 C —C₂H₄— 1 — — 1 451 Cl H O — 1 C —C₂H₄— 1 — — 2 452 Cl H O — 1 C —C₄H₈— 1 — — 1 453 Cl H O — 2 Si CH₃ 2 — — 0 454 Cl H O — 0 S(O)_(r) — 0 — 0 1 455 Cl H O — 1 S(O)_(r) — 0 — 0 0 456 Cl H O — 0 S(O)_(r) — 0 — 2 1 457 Cl H O — 1 S(O)_(r) — 0 — 2 0 458 Cl H O — 1 N(═O)_(q) CH₃ 1 0 — 0 459 Cl H O — 1 N(═O)_(q) CH₃ 1 1 — 0 460 Cl H O — 0 C═O — 0 — — 0 461 Cl H O 0 C═O — 0 — — 1 462 Cl H O 1 C═O — 0 — — 0 463 Cl Cl O — 1 CH OH 1 — — 1 464 Cl Cl O — 1 CH OCH₃ 1 — — 0 465 Cl Cl O — 1 C —C₂H₄— 1 — — 1 466 Cl Cl O — 1 C —C₂H₄— 1 — — 2 467 Cl Cl O — 1 C —C₄H₈— 1 — — 1 468 Cl Cl O — 2 Si CH₃ 2 — — 0 469 Cl Cl O — 0 S(O)_(r) — 0 — 0 1 470 Cl Cl O — 1 S(O)_(r) — 0 — 0 0 471 Cl Cl O — 0 S(O)_(r) — 0 — 2 1 472 Cl Cl O — 1 S(O)_(r) — 0 — 2 0 473 Cl Cl O — 1 N(═O)_(q) CH₃ 1 0 — 0 474 Cl Cl O — 1 N(═O)_(q) CH₃ 1 1 — 0 475 Cl Cl O — 0 C═O — 0 — — 0 476 Cl Cl O 0 C═O — 0 — — 1 477 Cl Cl O 1 C═O — 0 — — 0 478 H CH₃ O — 1 CH OH 1 — — 1 479 H CH₃ O — 1 CH OCH₃ 1 — — 0 480 H CH₃ O — 1 C —C₂H₄— 1 — — 1 481 H CH₃ O — 1 C —C₂H₄— 1 — — 2 482 H CH₃ O — 1 C —C₄H₈— 1 — — 1 483 H CH₃ O — 2 Si CH₃ 2 — — 0 484 H CH₃ O — 0 S(O)_(r) — 0 — 0 1 485 H CH₃ O — 1 S(O)_(r) — 0 — 0 0 486 H CH₃ O — 0 S(O)_(r) — 0 — 2 1 487 H CH₃ O — 1 S(O)_(r) — 0 — 2 0 488 H CH₃ O — 1 N(═O)_(q) CH₃ 1 0 — 0 489 H CH₃ O — 1 N(═O)_(q) CH₃ 1 1 — 0 490 H CH₃ O — 0 C═O — 0 — — 0 491 H CH₃ O 0 C═O — 0 — — 1 492 H CH₃ O 1 C═O — 0 — — 0 493 CH₃ H O — 1 CH OH 1 — — 1 494 CH₃ H O — 1 CH OCH₃ 1 — — 0 495 CH₃ H O — 1 C —C₂H₄— 1 — — 1 496 CH₃ H O — 1 C —C₂H₄— 1 — — 2 497 CH₃ H O — 1 C —C₄H₈— 1 — — 1 498 CH₃ H O — 2 Si CH₃ 2 — — 0 499 CH₃ H O — 0 S(O)_(r) — 0 — 0 1 500 CH₃ H O — 1 S(O)_(r) — 0 — 0 0 501 CH₃ H O — 0 S(O)_(r) — 0 — 2 1 502 CH₃ H O — 1 S(O)_(r) — 0 — 2 0 503 CH₃ H O — 1 N(═O)_(q) CH₃ 1 0 — 0 504 CH₃ H O — 1 N(═O)_(q) CH₃ 1 1 — 0 505 CH₃ H O — 0 C═O — 0 — — 0 506 CH₃ H O 0 C═O — 0 — — 1 507 CH₃ H O 1 C═O — 0 — — 0 508 CH₃ CH₃ O — 1 CH OH 1 — — 1 509 CH₃ CH₃ O — 1 CH OCH₃ 1 — — 0 510 CH₃ CH₃ O — 1 C —C₂H₄— 1 — — 1 511 CH₃ CH₃ O — 1 C —C₂H₄— 1 — — 2 512 CH₃ CH₃ O — 1 C —C₄H₈— 1 — — 1 513 CH₃ CH₃ O — 2 Si CH₃ 2 — — 0 514 CH₃ CH₃ O — 0 S(O)_(r) — 0 — 0 1 515 CH₃ CH₃ O — 1 S(O)_(r) — 0 — 0 0 516 CH₃ CH₃ O — 0 S(O)_(r) — 0 — 2 1 517 CH₃ CH₃ O — 1 S(O)_(r) — 0 — 2 0 518 CH₃ CH₃ O — 1 N(═O)_(q) CH₃ 1 0 — 0 519 CH₃ CH₃ O — 1 N(═O)_(q) CH₃ 1 1 — 0 520 CH₃ CH₃ O — 0 C═O — 0 — — 0 521 CH₃ CH₃ O — 0 C═O — 0 — — 1 522 CH₃ CH₃ O — 1 C═O — 0 — — 0 523 H H NR³ H 1 CH OH 1 — — 1 524 H H NR³ H 1 CH OCH₃ 1 — — 0 525 H H NR³ H 1 C —C₂H₄— 1 — — 1 526 H H NR³ H 1 C —C₂H₄— 1 — — 2 527 H H NR³ H 1 C —C₄H₈— 1 — — 1 528 H H NR³ H 2 Si CH₃ 2 — — 0 529 H H NR³ H 0 S(O)_(r) — 0 — 0 1 530 H H NR³ H 1 S(O)_(r) — 0 — 0 0 531 H H NR³ H 0 S(O)_(r) — 0 — 2 1 532 H H NR³ H 1 S(O)_(r) — 0 — 2 0 533 H H NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 534 H H NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 535 H H NR³ H 0 C═O — 0 — — 0 536 H H NR³ H 0 C═O — 0 — — 1 537 H H NR³ H 1 C═O — 0 — — 0 538 H Cl NR³ H 1 CH OH 1 — — 1 539 H Cl NR³ H 1 CH OCH₃ 1 — — 0 540 H Cl NR³ H 1 C —C₂H₄— 1 — — 1 541 H Cl NR³ H 1 C —C₂H₄— 1 — — 2 542 H Cl NR³ H 1 C —C₄H₈— 1 — — 1 543 H Cl NR³ H 2 Si CH₃ 2 — — 0 544 H Cl NR³ H 0 S(O)_(r) — 0 — 0 1 545 H Cl NR³ H 1 S(O)_(r) — 0 — 0 0 546 H Cl NR³ H 0 S(O)_(r) — 0 — 2 1 547 H Cl NR³ H 1 S(O)_(r) — 0 — 2 0 548 H Cl NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 549 H Cl NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 550 H Cl NR³ H 0 C═O — 0 — — 0 551 H Cl NR³ H 0 C═O — 0 — — 1 552 H Cl NR³ H 1 C═O — 0 — — 0 553 Cl H NR³ H 1 CH OH 1 — — 1 554 Cl H NR³ H 1 CH OCH₃ 1 — — 0 555 Cl H NR³ H 1 C —C₂H₄— 1 — — 1 556 Cl H NR³ H 1 C —C₂H₄— 1 — — 2 557 Cl H NR³ H 1 C —C₄H₈— 1 — — 1 558 Cl H NR³ H 2 Si CH₃ 2 — — 0 559 Cl H NR³ H 0 S(O)_(r) — 0 — 0 1 560 Cl H NR³ H 1 S(O)_(r) — 0 — 0 0 561 Cl H NR³ H 0 S(O)_(r) — 0 — 2 1 562 Cl H NR³ H 1 S(O)_(r) — 0 — 2 0 563 Cl H NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 564 Cl H NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 565 Cl H NR³ H 0 C═O — 0 — — 0 566 Cl H NR³ H 0 C═O — 0 — — 1 567 Cl H NR³ H 1 C═O — 0 — — 0 568 Cl Cl NR³ H 1 CH OH 1 — — 1 569 Cl Cl NR³ H 1 CH OCH₃ 1 — — 0 570 Cl Cl NR³ H 1 C —C₂H₄— 1 — — 1 571 Cl Cl NR³ H 1 C —C₂H₄— 1 — — 2 572 Cl Cl NR³ H 1 C —C₄H₈— 1 — — 1 573 Cl Cl NR³ H 2 Si CH₃ 2 — — 0 574 Cl Cl NR³ H 0 S(O)_(r) — 0 — 0 1 575 Cl Cl NR³ H 1 S(O)_(r) — 0 — 0 0 576 Cl Cl NR³ H 0 S(O)_(r) — 0 — 2 1 577 Cl Cl NR³ H 1 S(O)_(r) — 0 — 2 0 578 Cl Cl NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 579 Cl Cl NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 580 Cl Cl NR³ H 0 C═O — 0 — — 0 581 Cl Cl NR³ H 0 C═O — 0 — — 1 582 Cl Cl NR³ H 1 C═O — 0 — — 0 583 H CH₃ NR³ H 1 CH OH 1 — — 1 584 H CH₃ NR³ H 1 CH OCH₃ 1 — — 0 585 H CH₃ NR³ H 1 C —C₂H₄— 1 — — 1 586 H CH₃ NR³ H 1 C —C₂H₄— 1 — — 2 587 H CH₃ NR³ H 1 C —C₄H₈— 1 — — 1 588 H CH₃ NR³ H 2 Si CH₃ 2 — — 0 589 H CH₃ NR³ H 0 S(O)_(r) — 0 — 0 1 590 H CH₃ NR³ H 1 S(O)_(r) — 0 — 0 0 591 H CH₃ NR³ H 0 S(O)_(r) — 0 — 2 1 592 H CH₃ NR³ H 1 S(O)_(r) — 0 — 2 0 593 H CH₃ NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 594 H CH₃ NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 595 H CH₃ NR³ H 0 C═O — 0 — — 0 596 H CH₃ NR³ H 0 C═O — 0 — — 1 597 H CH₃ NR³ H 1 C═O — 0 — — 0 598 CH₃ H NR³ H 1 CH OH 1 — — 1 599 CH₃ H NR³ H 1 CH OCH₃ 1 — — 0 600 CH₃ H NR³ H 1 C —C₂H₄— 1 — — 1 601 CH₃ H NR³ H 1 C —C₂H₄— 1 — — 2 602 CH₃ H NR³ H 1 C —C₄H₈— 1 — — 1 603 CH₃ H NR³ H 2 Si CH₃ 2 — — 0 604 CH₃ H NR³ H 0 S(O)_(r) — 0 — 0 1 605 CH₃ H NR³ H 1 S(O)_(r) — 0 — 0 0 606 CH₃ H NR³ H 0 S(O)_(r) — 0 — 2 1 607 CH₃ H NR³ H 1 S(O)_(r) — 0 — 2 0 608 CH₃ H NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 609 CH₃ H NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 610 CH₃ H NR³ H 0 C═O — 0 — — 0 611 CH₃ H NR³ H 0 C═O — 0 — — 1 612 CH₃ H NR³ H 1 C═O — 0 — — 0 613 CH₃ CH₃ NR³ H 1 CH OH 1 — — 1 614 CH₃ CH₃ NR³ H 1 CH OCH₃ 1 — — 0 615 CH₃ CH₃ NR³ H 1 C —C₂H₄— 1 — — 1 616 CH₃ CH₃ NR³ H 1 C —C₂H₄— 1 — — 2 617 CH₃ CH₃ NR³ H 1 C —C₄H₈— 1 — — 1 618 CH₃ CH₃ NR³ H 2 Si CH₃ 2 — — 0 619 CH₃ CH₃ NR³ H 0 S(O)_(r) — 0 — 0 1 620 CH₃ CH₃ NR³ H 1 S(O)_(r) — 0 — 0 0 621 CH₃ CH₃ NR³ H 0 S(O)_(r) — 0 — 2 1 622 CH₃ CH₃ NR³ H 1 S(O)_(r) — 0 — 2 0 623 CH₃ CH₃ NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 624 CH₃ CH₃ NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 625 CH₃ CH₃ NR³ H 0 C═O — 0 — — 0 626 CH₃ CH₃ NR³ H 0 C═O — 0 — — 1 627 CH₃ CH₃ NR³ H 1 C═O — 0 — — 0 628 —CH═CHCH═CH— O — 1 CH OH 1 — — 0 629 —CH═CHCH═CH— O — 0 CH OH 1 — — 1 630 —CH═CHCH═CH— O — 1 CH OH 1 — — 1 631 —CH═CHCH═CH— O — 0 CH OCH₃ 1 — — 0 632 —CH═CHCH═CH— O — 1 CH OCH₃ 1 — — 0 633 —CH═CHCH═CH— O — 0 CH OCH₃ 1 — — 1 635 —CH═CHCH═CH— O — 1 CH OCH₃ 1 — — 0 636 —CH═CHCH═CH— O — 0 C —C₂H₄— 1 — — 1 637 —CH═CHCH═CH— O — 1 C —C₂H₄— 1 — — 0 638 —CH═CHCH═CH— O — 1 C —C₂H₄— 1 — — 1 639 —CH═CHCH═CH— O — 2 C —C₂H₄— 1 — — 0 640 —CH═CHCH═CH— O — 1 C —C₂H₄— 1 — — 2 641 —CH═CHCH═CH— O — 0 C —C₄H₈— 1 — — 1 642 —CH═CHCH═CH— O — 1 C —C₄H₈— 1 — — 0 643 —CH═CHCH═CH— O — 1 C —C₄H₈— 1 — — 1 644 —CH═CHCH═CH— O — 2 C —C₄H₈— 1 — — 0 645 —CH═CHCH═CH— O — 1 C —C₄H₈— 1 — — 2 646 —CH═CHCH═CH— O — 1 Si CH₃ 2 — — 0 647 —CH═CHCH═CH— O — 2 Si CH₃ 2 — — 0 648 —CH═CHCH═CH— O — 3 Si CH₃ 2 — — 0 649 —CH═CHCH═CH— O — 0 S(O)_(r) — 0 — 0 1 650 —CH═CHCH═CH— O — 1 S(O)_(r) — 0 — 0 0 652 —CH═CHCH═CH— O — 2 S(O)_(r) — 0 — 0 0 653 —CH═CHCH═CH— O — 2 S(O)_(r) — 0 — 0 1 654 —CH═CHCH═CH— O — 0 S(O)_(r) — 0 — 2 1 655 —CH═CHCH═CH— O — 1 S(O)_(r) — 0 — 2 0 656 —CH═CHCH═CH— O — 2 S(O)_(r) — 0 — 2 0 657 —CH═CHCH═CH— O — 2 S(O)_(r) — 0 — 2 1 658 —CH═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 659 —CH═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 1 660 —CH═CHCH═CH— O — 2 N(═O)_(q) CH₃ 1 0 — 0 661 —CH═CHCH═CH— O — 2 N(═O)_(q) CH₃ 1 0 — 1 662 —CH═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 663 —CH═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 1 664 —CH═CHCH═CH— O — 2 N(═O)_(q) CH₃ 1 1 — 0 665 —CH═CHCH═CH— O — 2 N(═O)_(q) CH₃ 1 1 — 1 666 —CH═CHCH═CH— O — 0 C═O — 0 — — 0 667 —CH═CHCH═CH— O — 0 C═O — 0 — — 1 668 —CH═CHCH═CH— O — 1 C═O — 0 — — 0 669 —CH═CHCH═CH— O — 1 C═O — 0 — — 1 670 —C(F)═CHCH═CH— O — 1 CH OH 1 — — 1 671 —C(F)═CHCH═CH— O — 1 CH OCH₃ 1 — — 0 672 —C(F)═CHCH═CH— O — 1 C —C₂H₄— 1 — — 1 673 —C(F)═CHCH═CH— O — 1 C —C₂H₄— 1 — — 2 674 —C(F)═CHCH═CH— O — 1 C —C₄H₈— 1 — — 1 675 —C(F)═CHCH═CH— O — 2 Si CH₃ 2 — — 0 676 —C(F)═CHCH═CH— O — 0 S(O)_(r) — 0 — 0 1 677 —C(F)═CHCH═CH— O — 1 S(O)_(r) — 0 — 0 0 678 —C(F)═CHCH═CH— O — 0 S(O)_(r) — 0 — 2 1 679 —C(F)═CHCH═CH— O — 1 S(O)_(r) — 0 — 2 0 680 —C(F)═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 681 —C(F)═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 682 —C(F)═CHCH═CH— O — 0 C═O — 0 — — 0 683 —C(F)═CHCH═CH— O — 0 C═O — 0 — — 1 684 —C(F)═CHCH═CH— O — 1 C═O — 0 — — 0 685 —CH═C(F)CH═CH— O — 1 CH OH 1 — — 1 686 —CH═C(F)CH═CH— O — 1 CH OCH₃ 1 — — 0 687 —CH═C(F)CH═CH— O — 1 C —C₂H₄— 1 — — 1 688 —CH═C(F)CH═CH— O — 1 C —C₂H₄— 1 — — 2 689 —CH═C(F)CH═CH— O — 1 C —C₄H₈— 1 — — 1 690 —CH═C(F)CH═CH— O — 2 Si CH₃ 2 — — 0 691 —CH═C(F)CH═CH— O — 0 S(O)_(r) — 0 — 0 1 692 —CH═C(F)CH═CH— O — 1 S(O)_(r) — 0 — 0 0 693 —CH═C(F)CH═CH— O — 0 S(O)_(r) — 0 — 2 1 694 —CH═C(F)CH═CH— O — 1 S(O)_(r) — 0 — 2 0 695 —CH═C(F)CH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 696 —CH═C(F)CH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 697 —CH═C(F)CH═CH— O — 0 C═O — 0 — — 0 698 —CH═C(F)CH═CH— O — 0 C═O — 0 — — 1 699 —CH═C(F)CH═CH— O — 1 C═O — 0 — — 0 700 —C(F)═C(F)CH═CH— O — 1 CH OH 1 — — 1 701 —C(F)═C(F)CH═CH— O — 1 CH OCH₃ 1 — — 0 702 —C(F)═C(F)CH═CH— O — 1 C —C₂H₄— 1 — — 1 703 —C(F)═C(F)CH═CH— O — 1 C —C₂H₄— 1 — — 2 704 —C(F)═C(F)CH═CH— O — 1 C —C₄H₈— 1 — — 1 705 —C(F)═C(F)CH═CH— O — 2 Si CH₃ 2 — — 0 706 —C(F)═C(F)CH═CH— O — 0 S(O)_(r) — 0 — 0 1 707 —C(F)═C(F)CH═CH— O — 1 S(O)_(r) — 0 — 0 0 708 —C(F)═C(F)CH═CH— O — 0 S(O)_(r) — 0 — 2 1 709 —C(F)═C(F)CH═CH— O — 1 S(O)_(r) — 0 — 2 0 710 —C(F)═C(F)CH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 711 —C(F)═C(F)CH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 712 —C(F)═C(F)CH═CH— O — 0 C═O — 0 — — 0 713 —C(F)═C(F)CH═CH— O — 0 C═O — 0 — — 1 714 —C(F)═C(F)CH═CH— O — 1 C═O — 0 — — 0 715 —C(F)═CHC(F)═CH— O — 1 CH OH 1 — — 1 716 —C(F)═CHC(F)═CH— O — 1 CH OCH₃ 1 — — 0 717 —C(F)═CHC(F)═CH— O — 1 C —C₂H₄— 1 — — 1 718 —C(F)═CHC(F)═CH— O — 1 C —C₂H₄— 1 — — 2 719 —C(F)═CHC(F)═CH— O — 1 C —C₄H₈— 1 — — 1 720 —C(F)═CHC(F)═CH— O — 2 Si CH₃ 2 — — 0 721 —C(F)═CHC(F)═CH— O — 0 S(O)_(r) — 0 — 0 1 722 —C(F)═CHC(F)═CH— O — 1 S(O)_(r) — 0 — 0 0 723 —C(F)═CHC(F)═CH— O — 0 S(O)_(r) — 0 — 2 1 724 —C(F)═CHC(F)═CH— O — 1 S(O)_(r) — 0 — 2 0 725 —C(F)═CHC(F)═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 726 —C(F)═CHC(F)═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 727 —C(F)═CHC(F)═CH— O — 0 C═O — 0 — — 0 728 —C(F)═CHC(F)═CH— O — 0 C═O — 0 — — 1 729 —C(F)═CHC(F)═CH— O — 1 C═O — 0 — — 0 730 —CH═C(F)C(F)═CH— O — 1 CH OH 1 — — 1 731 —CH═C(F)C(F)═CH— O — 1 CH OCH₃ 1 — — 0 732 —CH═C(F)C(F)═CH— O — 1 C —C₂H₄— 1 — — 1 733 —CH═C(F)C(F)═CH— O — 1 C —C₂H₄— 1 — — 2 734 —CH═C(F)C(F)═CH— O — 1 C —C₄H₈— 1 — — 1 735 —CH═C(F)C(F)═CH— O — 2 Si CH₃ 2 — — 0 736 —CH═C(F)C(F)═CH— O — 0 S(O)_(r) — 0 — 0 1 737 —CH═C(F)C(F)═CH— O — 1 S(O)_(r) — 0 — 0 0 738 —CH═C(F)C(F)═CH— O — 0 S(O)_(r) — 0 — 2 1 739 —CH═C(F)C(F)═CH— O — 1 S(O)_(r) — 0 — 2 0 740 —CH═C(F)C(F)═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 741 —CH═C(F)C(F)═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 742 —CH═C(F)C(F)═CH— O — 0 C═O — 0 — — 0 743 —CH═C(F)C(F)═CH— O — 0 C═O — 0 — — 1 744 —CH═C(F)C(F)═CH— O — 1 C═O — 0 — — 0 745 —C(CH₃)═CHCH═CH— O — 1 CH OH 1 — — 1 746 —C(CH₃)═CHCH═CH— O — 1 CH OCH₃ 1 — — 0 747 —C(CH₃)═CHCH═CH— O — 1 C —C₂H₄— 1 — — 1 748 —C(CH₃)═CHCH═CH— O — 1 C —C₂H₄— 1 — — 2 749 —C(CH₃)═CHCH═CH— O — 1 C —C₄H₈— 1 — — 1 750 —C(CH₃)═CHCH═CH— O — 2 Si CH₃ 2 — — 0 751 —C(CH₃)═CHCH═CH— O — 0 S(O)_(r) — 0 — 0 1 752 —C(CH₃)═CHCH═CH— O — 1 S(O)_(r) — 0 — 0 0 753 —C(CH₃)═CHCH═CH— O — 0 S(O)_(r) — 0 — 2 1 754 —C(CH₃)═CHCH═CH— O — 1 S(O)_(r) — 0 — 2 0 755 —C(CH₃)═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 756 —C(CH₃)═CHCH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 757 —C(CH₃)═CHCH═CH— O — 0 C═O — 0 — — 0 758 —C(CH₃)═CHCH═CH— O — 0 C═O — 0 — — 1 759 —C(CH₃)═CHCH═CH— O — 1 C═O — 0 — — 0 760 —CH═CHC(CH₃)═CH— O — 1 CH OH 1 — — 1 761 —CH═CHC(CH₃)═CH— O — 1 CH OCH₃ 1 — — 0 762 —CH═CHC(CH₃)═CH— O — 1 C —C₂H₄— 1 — — 1 763 —CH═CHC(CH₃)═CH— O — 1 C —C₂H₄— 1 — — 2 764 —CH═CHC(CH₃)═CH— O — 1 C —C₄H₈— 1 — — 1 765 —CH═CHC(CH₃)═CH— O — 2 Si CH₃ 2 — — 0 766 —CH═CHC(CH₃)═CH— O — 0 S(O)_(r) — 0 — 0 1 767 —CH═CHC(CH₃)═CH— O — 1 S(O)_(r) — 0 — 0 0 768 —CH═CHC(CH₃)═CH— O — 0 S(O)_(r) — 0 — 2 1 769 —CH═CHC(CH₃)═CH— O — 1 S(O)_(r) — 0 — 2 0 770 —CH═CHC(CH₃)═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 771 —CH═CHC(CH₃)═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 772 —CH═CHC(CH₃)═CH— O — 0 C═O — 0 — — 0 773 —CH═CHC(CH₃)═CH— O — 0 C═O — 0 — — 1 774 —CH═CHC(CH₃)═CH— O — 1 C═O — 0 — — 0 775 —CH═C(CH₃)CH═CH— O — 1 CH OH 1 — — 1 776 —CH═C(CH₃)CH═CH— O — 1 CH OCH₃ 1 — — 0 777 —CH═C(CH₃)CH═CH— O — 1 C —C₂H₄— 1 — — 1 778 —CH═C(CH₃)CH═CH— O — 1 C —C₂H₄— 1 — — 2 779 —CH═C(CH₃)CH═CH— O — 1 C —C₄H₈— 1 — — 1 780 —CH═C(CH₃)CH═CH— O — 2 Si CH₃ 2 — — 0 781 —CH═C(CH₃)CH═CH— O — 0 S(O)_(r) — 0 — 0 1 782 —CH═C(CH₃)CH═CH— O — 1 S(O)_(r) — 0 — 0 0 783 —CH═C(CH₃)CH═CH— O — 0 S(O)_(r) — 0 — 2 1 784 —CH═C(CH₃)CH═CH— O — 1 S(O)_(r) — 0 — 2 0 785 —CH═C(CH₃)CH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 786 —CH═C(CH₃)CH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 787 —CH═C(CH₃)CH═CH— O — 0 C═O — 0 — — 0 788 —CH═C(CH₃)CH═CH— O — 0 C═O — 0 — — 1 789 —CH═C(CH₃)CH═CH— O — 1 C═O — 0 — — 0 790 —CH═CHCH═C(CH₃)— O — 1 CH OH 1 — — 1 791 —CH═CHCH═C(CH₃)— O — 1 CH OCH₃ 1 — — 0 792 —CH═CHCH═C(CH₃)— O — 1 C —C₂H₄— 1 — — 1 793 —CH═CHCH═C(CH₃)— O — 1 C —C₂H₄— 1 — — 2 794 —CH═CHCH═C(CH₃)— O — 1 C —C₄H₈— 1 — — 1 795 —CH═CHCH═C(CH₃)— O — 2 Si CH₃ 2 — — 0 796 —CH═CHCH═C(CH₃)— O — 0 S(O)_(r) — 0 — 0 1 797 —CH═CHCH═C(CH₃)— O — 1 S(O)_(r) — 0 — 0 0 798 —CH═CHCH═C(CH₃)— O — 0 S(O)_(r) — 0 — 2 1 799 —CH═CHCH═C(CH₃)— O — 1 S(O)_(r) — 0 — 2 0 800 —CH═CHCH═C(CH₃)— O — 1 N(═O)_(q) CH₃ 1 0 — 0 801 —CH═CHCH═C(CH₃)— O — 1 N(═O)_(q) CH₃ 1 1 — 0 802 —CH═CHCH═C(CH₃)— O — 0 C═O — 0 — — 0 803 —CH═CHCH═C(CH₃)— O — 0 C═O — 0 — — 1 804 —CH═CHCH═C(CH₃)— O — 1 C═O — 0 — — 0 805 —C(CH₃)═C(CH₃)CH═CH— O — 1 CH OH 1 — — 1 806 —C(CH₃)═C(CH₃)CH═CH— O — 1 CH OCH₃ 1 — — 0 807 —C(CH₃)═C(CH₃)CH═CH— O — 1 C —C₂H₄— 1 — — 1 808 —C(CH₃)═C(CH₃)CH═CH— O — 1 C —C₂H₄— 1 — — 2 809 —C(CH₃)═C(CH₃)CH═CH— O — 1 C —C₄H₈— 1 — — 1 810 —C(CH₃)═C(CH₃)CH═CH— O — 2 Si CH₃ 2 — — 0 811 —C(CH₃)═C(CH₃)CH═CH— O — 0 S(O)_(r) — 0 — 0 1 812 —C(CH₃)═C(CH₃)CH═CH— O — 1 S(O)_(r) — 0 — 0 0 813 —C(CH₃)═C(CH₃)CH═CH— O — 0 S(O)_(r) — 0 — 2 1 814 —C(CH₃)═C(CH₃)CH═CH— O — 1 S(O)_(r) — 0 — 2 0 815 —C(CH₃)═C(CH₃)CH═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 816 —C(CH₃)═C(CH₃)CH═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 817 —C(CH₃)═C(CH₃)CH═CH— O — 0 C═O — 0 — — 0 818 —C(CH₃)═C(CH₃)CH═CH— O — 0 C═O — 0 — — 1 819 —C(CH₃)═C(CH₃)CH═CH— O — 1 C═O — 0 — — 0 820 —C(CH₃)═CHC(CH₃)═CH— O — 1 CH OH 1 — — 1 821 —C(CH₃)═CHC(CH₃)═CH— O — 1 CH OCH₃ 1 — — 0 822 —C(CH₃)═CHC(CH₃)═CH— O — 1 C —C₂H₄— 1 — — 1 823 —C(CH₃)═CHC(CH₃)═CH— O — 1 C —C₂H₄— 1 — — 2 824 —C(CH₃)═CHC(CH₃)═CH— O — 1 C —C₄H₈— 1 — — 1 825 —C(CH₃)═CHC(CH₃)═CH— O — 2 Si CH₃ 2 — — 0 826 —C(CH₃)═CHC(CH₃)═CH— O — 0 S(O)_(r) — 0 — 0 1 827 —C(CH₃)═CHC(CH₃)═CH— O — 1 S(O)_(r) — 0 — 0 0 828 —C(CH₃)═CHC(CH₃)═CH— O — 0 S(O)_(r) — 0 — 2 1 829 —C(CH₃)═CHC(CH₃)═CH— O — 1 S(O)_(r) — 0 — 2 0 830 —C(CH₃)═CHC(CH₃)═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 831 —C(CH₃)═CHC(CH₃)═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 832 —C(CH₃)═CHC(CH₃)═CH— O — 0 C═O — 0 — — 0 833 —C(CH₃)═CHC(CH₃)═CH— O — 0 C═O — 0 — — 1 834 —C(CH₃)═CHC(CH₃)═CH— O — 1 C═O — 0 — — 0 835 —CH═C(CH₃)C(CH₃)═CH— O — 1 CH OH 1 — — 1 836 —CH═C(CH₃)C(CH₃)═CH— O — 1 CH OCH₃ 1 — — 0 837 —CH═C(CH₃)C(CH₃)═CH— O — 1 C —C₂H₄— 1 — — 1 838 —CH═C(CH₃)C(CH₃)═CH— O — 1 C —C₂H₄— 1 — — 2 839 —CH═C(CH₃)C(CH₃)═CH— O — 1 C —C₄H₈— 1 — — 1 840 —CH═C(CH₃)C(CH₃)═CH— O — 2 Si CH₃ 2 — — 0 841 —CH═C(CH₃)C(CH₃)═CH— O — 0 S(O)_(r) — 0 — 0 1 842 —CH═C(CH₃)C(CH₃)═CH— O — 1 S(O)_(r) — 0 — 0 0 843 —CH═C(CH₃)C(CH₃)═CH— O — 0 S(O)_(r) — 0 — 2 1 844 —CH═C(CH₃)C(CH₃)═CH— O — 1 S(O)_(r) — 0 — 2 0 845 —CH═C(CH₃)C(CH₃)═CH— O — 1 N(═O)_(q) CH₃ 1 0 — 0 846 —CH═C(CH₃)C(CH₃)═CH— O — 1 N(═O)_(q) CH₃ 1 1 — 0 847 —CH═C(CH₃)C(CH₃)═CH— O — 0 C═O — 0 — — 0 848 —CH═C(CH₃)C(CH₃)═CH— O — 0 C═O — 0 — — 1 849 —CH═C(CH₃)C(CH₃)═CH— O — 1 C═O — 0 — — 0 850 —C(CH₃)═CHCH═C(CH₃)— O — 1 CH OH 1 — — 1 851 —C(CH₃)═CHCH═C(CH₃)— O — 1 CH OCH₃ 1 — — 0 852 —C(CH₃)═CHCH═C(CH₃)— O — 1 C —C₂H₄— 1 — — 1 853 —C(CH₃)═CHCH═C(CH₃)— O — 1 C —C₂H₄— 1 — — 2 854 —C(CH₃)═CHCH═C(CH₃)— O — 1 C —C₄H₈— 1 — — 1 855 —C(CH₃)═CHCH═C(CH₃)— O — 2 Si CH₃ 2 — — 0 856 —C(CH₃)═CHCH═C(CH₃)— O — 0 S(O)_(r) — 0 — 0 1 857 —C(CH₃)═CHCH═C(CH₃)— O — 1 S(O)_(r) — 0 — 0 0 858 —C(CH₃)═CHCH═C(CH₃)— O — 0 S(O)_(r) — 0 — 2 1 859 —C(CH₃)═CHCH═C(CH₃)— O — 1 S(O)_(r) — 0 — 2 0 860 —C(CH₃)═CHCH═C(CH₃)— O — 1 N(═O)_(q) CH₃ 1 0 — 0 861 —C(CH₃)═CHCH═C(CH₃)— O — 1 N(═O)_(q) CH₃ 1 1 — 0 862 —C(CH₃)═CHCH═C(CH₃)— O — 0 C═O — 0 — — 0 863 —C(CH₃)═CHCH═C(CH₃)— O — 0 C═O — 0 — — 1 864 —C(CH₃)═CHCH═C(CH₃)— O — 1 C═O — 0 — — 0 865 —CH═CHCH═CH— NR³ H 0 CH OH 1 — — 0 866 —CH═CHCH═CH— NR³ H 1 CH OH 1 — — 0 867 —CH═CHCH═CH— NR³ H 0 CH OH 1 — — 1 868 —CH═CHCH═CH— NR³ H 1 CH OH 1 — — 1 869 —CH═CHCH═CH— NR³ H 0 CH OCH₃ 1 — — 0 870 —CH═CHCH═CH— NR³ H 1 CH OCH₃ 1 — — 0 871 —CH═CHCH═CH— NR³ H 0 CH OCH₃ 1 — — 1 872 —CH═CHCH═CH— NR³ H 1 CH OCH₃ 1 — — 0 873 —CH═CHCH═CH— NR³ H 0 C —C₂H₄— 1 — — 1 874 —CH═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 0 875 —CH═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 876 —CH═CHCH═CH— NR³ H 2 C —C₂H₄— 1 — — 0 877 —CH═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 878 —CH═CHCH═CH— NR³ H 0 C —C₄H₈— 1 — — 1 879 —CH═CHCH═CH— NR³ H 1 C —C₄H₈— 1 — — 0 880 —CH═CHCH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 881 —CH═CHCH═CH— NR³ H 2 C —C₄H₈— 1 — — 0 882 —CH═CHCH═CH— NR³ H 1 C —C₄H₈— 1 — — 2 883 —CH═CHCH═CH— NR³ H 1 Si CH₃ 2 — — 0 884 —CH═CHCH═CH— NR³ H 2 Si CH₃ 2 — — 0 885 —CH═CHCH═CH— NR³ H 3 Si CH₃ 2 — — 0 886 —CH═CHCH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 887 —CH═CHCH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 888 —CH═CHCH═CH— NR³ H 2 S(O)_(r) — 0 — 0 0 889 —CH═CHCH═CH— NR³ H 2 S(O)_(r) — 0 — 0 1 890 —CH═CHCH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 891 —CH═CHCH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 892 —CH═CHCH═CH— NR³ H 2 S(O)_(r) — 0 — 2 0 893 —CH═CHCH═CH— NR³ H 2 S(O)_(r) — 0 — 2 1 894 —CH═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 895 —CH═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 1 896 —CH═CHCH═CH— NR³ H 2 N(═O)_(q) CH₃ 1 0 — 0 897 —CH═CHCH═CH— NR³ H 2 N(═O)_(q) CH₃ 1 0 — 1 898 —CH═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 899 —CH═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 1 900 —CH═CHCH═CH— NR³ H 2 N(═O)_(q) CH₃ 1 1 — 0 901 —CH═CHCH═CH— NR³ H 2 N(═O)_(q) CH₃ 1 1 — 1 902 —CH═CHCH═CH— NR³ H 0 C═O — 0 — — 0 903 —CH═CHCH═CH— NR³ H 0 C═O — 0 — — 1 904 —CH═CHCH═CH— NR³ H 1 C═O — 0 — — 0 905 —CH═CHCH═CH— NR³ H 1 C═O — 0 — — 1 906 —C(F)═CHCH═CH— NR³ H 1 CH OH 1 — — 1 907 —C(F)═CHCH═CH— NR³ H 1 CH OCH₃ 1 — — 0 908 —C(F)═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 909 —C(F)═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 910 —C(F)═CHCH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 911 —C(F)═CHCH═CH— NR³ H 2 Si CH₃ 2 — — 0 912 —C(F)═CHCH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 913 —C(F)═CHCH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 914 —C(F)═CHCH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 915 —C(F)═CHCH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 916 —C(F)═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 917 —C(F)═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 918 —C(F)═CHCH═CH— NR³ H 0 C═O — 0 — — 0 919 —C(F)═CHCH═CH— NR³ H 0 C═O — 0 — — 1 920 —C(F)═CHCH═CH— NR³ H 1 C═O — 0 — — 0 921 —C(F)═CHCH═CH— NR³ H 1 C═O — 0 — — 1 922 —CH═C(F)CH═CH— NR³ H 1 CH OH 1 — — 1 923 —CH═C(F)CH═CH— NR³ H 1 CH OCH₃ 1 — — 0 924 —CH═C(F)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 925 —CH═C(F)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 926 —CH═C(F)CH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 927 —CH═C(F)CH═CH— NR³ H 2 Si CH₃ 2 — — 0 928 —CH═C(F)CH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 929 —CH═C(F)CH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 930 —CH═C(F)CH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 931 —CH═C(F)CH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 932 —CH═C(F)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 933 —CH═C(F)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 934 —CH═C(F)CH═CH— NR³ H 0 C═O — 0 — — 0 935 —CH═C(F)CH═CH— NR³ H 0 C═O — 0 — — 1 936 —CH═C(F)CH═CH— NR³ H 1 C═O — 0 — — 0 937 —C(F)═C(F)CH═CH— NR³ H 1 CH OH 1 — — 1 938 —C(F)═C(F)CH═CH— NR³ H 1 CH OCH₃ 1 — — 0 939 —C(F)═C(F)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 940 —C(F)═C(F)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 941 —C(F)═C(F)CH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 942 —C(F)═C(F)CH═CH— NR³ H 2 Si CH₃ 2 — — 0 943 —C(F)═C(F)CH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 944 —C(F)═C(F)CH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 945 —C(F)═C(F)CH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 946 —C(F)═C(F)CH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 947 —C(F)═C(F)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 948 —C(F)═C(F)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 949 —C(F)═C(F)CH═CH— NR³ H 0 C═O — 0 — — 0 950 —C(F)═C(F)CH═CH— NR³ H 0 C═O — 0 — — 1 951 —C(F)═C(F)CH═CH— NR³ H 1 C═O — 0 — — 0 952 —C(F)═CHC(F)═CH— NR³ H 1 CH OH 1 — — 1 953 —C(F)═CHC(F)═CH— NR³ H 1 CH OCH₃ 1 — — 0 954 —C(F)═CHC(F)═CH— NR³ H 1 C —C₂H₄— 1 — — 1 955 —C(F)═CHC(F)═CH— NR³ H 1 C —C₂H₄— 1 — — 2 956 —C(F)═CHC(F)═CH— NR³ H 1 C —C₄H₈— 1 — — 1 957 —C(F)═CHC(F)═CH— NR³ H 2 Si CH₃ 2 — — 0 958 —C(F)═CHC(F)═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 959 —C(F)═CHC(F)═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 960 —C(F)═CHC(F)═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 961 —C(F)═CHC(F)═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 962 —C(F)═CHC(F)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 963 —C(F)═CHC(F)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 964 —C(F)═CHC(F)═CH— NR³ H 0 C═O — 0 — — 0 965 —C(F)═CHC(F)═CH— NR³ H 0 C═O — 0 — — 1 966 —C(F)═CHC(F)═CH— NR³ H 1 C═O — 0 — — 0 967 —CH═C(F)C(F)═CH— NR³ H 1 CH OH 1 — — 1 968 —CH═C(F)C(F)═CH— NR³ H 1 CH OCH₃ 1 — — 0 969 —CH═C(F)C(F)═CH— NR³ H 1 C —C₂H₄— 1 — — 1 970 —CH═C(F)C(F)═CH— NR³ H 1 C —C₂H₄— 1 — — 2 971 —CH═C(F)C(F)═CH— NR³ H 1 C —C₄H₈— 1 — — 1 972 —CH═C(F)C(F)═CH— NR³ H 2 Si CH₃ 2 — — 0 973 —CH═C(F)C(F)═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 974 —CH═C(F)C(F)═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 975 —CH═C(F)C(F)═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 976 —CH═C(F)C(F)═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 977 —CH═C(F)C(F)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 978 —CH═C(F)C(F)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 979 —CH═C(F)C(F)═CH— NR³ H 0 C═O — 0 — — 0 980 —CH═C(F)C(F)═CH— NR³ H 0 C═O — 0 — — 1 981 —CH═C(F)C(F)═CH— NR³ H 1 C═O — 0 — — 0 982 —C(CH₃)═CHCH═CH— NR³ H 1 CH OH 1 — — 1 983 —C(CH₃)═CHCH═CH— NR³ H 1 CH OCH₃ 1 — — 0 984 —C(CH₃)═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 985 —C(CH₃)═CHCH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 986 —C(CH₃)═CHCH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 987 —C(CH₃)═CHCH═CH— NR³ H 2 Si CH₃ 2 — — 0 988 —C(CH₃)═CHCH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 989 —C(CH₃)═CHCH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 990 —C(CH₃)═CHCH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 991 —C(CH₃)═CHCH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 992 —C(CH₃)═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 993 —C(CH₃)═CHCH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 994 —C(CH₃)═CHCH═CH— NR³ H 0 C═O — 0 — — 0 995 —C(CH₃)═CHCH═CH— NR³ H 0 C═O — 0 — — 1 996 —C(CH₃)═CHCH═CH— NR³ H 1 C═O — 0 — — 0 997 —CH═CHC(CH₃)═CH— NR³ H 1 CH OH 1 — — 1 998 —CH═CHC(CH₃)═CH— NR³ H 1 CH OCH₃ 1 — — 0 999 —CH═CHC(CH₃)═CH— NR³ H 1 C —C₂H₄— 1 — — 1 1000 —CH═CHC(CH₃)═CH— NR³ H 1 C —C₂H₄— 1 — — 2 1001 —CH═CHC(CH₃)═CH— NR³ H 1 C —C₄H₈— 1 — — 1 1002 —CH═CHC(CH₃)═CH— NR³ H 2 Si CH₃ 2 — — 0 1003 —CH═CHC(CH₃)═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 1004 —CH═CHC(CH₃)═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 1005 —CH═CHC(CH₃)═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 1006 —CH═CHC(CH₃)═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 1007 —CH═CHC(CH₃)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1008 —CH═CHC(CH₃)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1009 —CH═CHC(CH₃)═CH— NR³ H 0 C═O — 0 — — 0 1010 —CH═CHC(CH₃)═CH— NR³ H 0 C═O — 0 — — 1 1011 —CH═CHC(CH₃)═CH— NR³ H 1 C═O — 0 — — 0 1012 —CH═C(CH₃)CH═CH— NR³ H 1 CH OH 1 — — 1 1013 —CH═C(CH₃)CH═CH— NR³ H 1 CH OCH₃ 1 — — 0 1014 —CH═C(CH₃)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 1015 —CH═C(CH₃)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 1016 —CH═C(CH₃)CH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 1017 —CH═C(CH₃)CH═CH— NR³ H 2 Si CH₃ 2 — — 0 1018 —CH═C(CH₃)CH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 1019 —CH═C(CH₃)CH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 1020 —CH═C(CH₃)CH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 1021 —CH═C(CH₃)CH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 1022 —CH═C(CH₃)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1023 —CH═C(CH₃)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1024 —CH═C(CH₃)CH═CH— NR³ H 0 C═O — 0 — — 0 1025 —CH═C(CH₃)CH═CH— NR³ H 0 C═O — 0 — — 1 1026 —CH═C(CH₃)CH═CH— NR³ H 1 C═O — 0 — — 0 1027 —CH═CHCH═C(CH₃)— NR³ H 1 CH OH 1 — — 1 1028 —CH═CHCH═C(CH₃)— NR³ H 1 CH OCH₃ 1 — — 0 1029 —CH═CHCH═C(CH₃)— NR³ H 1 C —C₂H₄— 1 — — 1 1030 —CH═CHCH═C(CH₃)— NR³ H 1 C —C₂H₄— 1 — — 2 1031 —CH═CHCH═C(CH₃)— NR³ H 1 C —C₄H₈— 1 — — 1 1032 —CH═CHCH═C(CH₃)— NR³ H 2 Si CH₃ 2 — — 0 1033 —CH═CHCH═C(CH₃)— NR³ H 0 S(O)_(r) — 0 — 0 1 1034 —CH═CHCH═C(CH₃)— NR³ H 1 S(O)_(r) — 0 — 0 0 1035 —CH═CHCH═C(CH₃)— NR³ H 0 S(O)_(r) — 0 — 2 1 1036 —CH═CHCH═C(CH₃)— NR³ H 1 S(O)_(r) — 0 — 2 0 1037 —CH═CHCH═C(CH₃)— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1038 —CH═CHCH═C(CH₃)— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1039 —CH═CHCH═C(CH₃)— NR³ H 0 C═O — 0 — — 0 1040 —CH═CHCH═C(CH₃)— NR³ H 0 C═O — 0 — — 1 1041 —CH═CHCH═C(CH₃)— NR³ H 1 C═O — 0 — — 0 1042 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 CH OH 1 — — 1 1043 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 CH OCH₃ 1 — — 0 1044 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 1 1045 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 C —C₂H₄— 1 — — 2 1046 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 C —C₄H₈— 1 — — 1 1047 —C(CH₃)═C(CH₃)CH═CH— NR³ H 2 Si CH₃ 2 — — 0 1048 —C(CH₃)═C(CH₃)CH═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 1049 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 1050 —C(CH₃)═C(CH₃)CH═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 1051 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 1052 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1053 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1054 —C(CH₃)═C(CH₃)CH═CH— NR³ H 0 C═O — 0 — — 0 1055 —C(CH₃)═C(CH₃)CH═CH— NR³ H 0 C═O — 0 — — 1 1056 —C(CH₃)═C(CH₃)CH═CH— NR³ H 1 C═O — 0 — — 0 1057 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 CH OH 1 — — 1 1058 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 CH OCH₃ 1 — — 0 1059 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 C —C₂H₄— 1 — — 1 1060 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 C —C₂H₄— 1 — — 2 1061 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 C —C₄H₈— 1 — — 1 1062 —C(CH₃)═CHC(CH₃)═CH— NR³ H 2 Si CH₃ 2 — — 0 1063 —C(CH₃)═CHC(CH₃)═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 1064 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 1065 —C(CH₃)═CHC(CH₃)═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 1066 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 1067 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1068 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1069 —C(CH₃)═CHC(CH₃)═CH— NR³ H 0 C═O — 0 — — 0 1070 —C(CH₃)═CHC(CH₃)═CH— NR³ H 0 C═O — 0 — — 1 1071 —C(CH₃)═CHC(CH₃)═CH— NR³ H 1 C═O — 0 — — 0 1072 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 CH OH 1 — — 1 1073 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 CH OCH₃ 1 — — 0 1074 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 C —C₂H₄— 1 — — 1 1075 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 C —C₂H₄— 1 — — 2 1076 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 C —C₄H₈— 1 — — 1 1077 —CH═C(CH₃)C(CH₃)═CH— NR³ H 2 Si CH₃ 2 — — 0 1078 —CH═C(CH₃)C(CH₃)═CH— NR³ H 0 S(O)_(r) — 0 — 0 1 1079 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 S(O)_(r) — 0 — 0 0 1080 —CH═C(CH₃)C(CH₃)═CH— NR³ H 0 S(O)_(r) — 0 — 2 1 1081 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 S(O)_(r) — 0 — 2 0 1082 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1083 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1084 —CH═C(CH₃)C(CH₃)═CH— NR³ H 0 C═O — 0 — — 0 1085 —CH═C(CH₃)C(CH₃)═CH— NR³ H 0 C═O — 0 — — 1 1086 —CH═C(CH₃)C(CH₃)═CH— NR³ H 1 C═O — 0 — — 0 1087 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 CH OH 1 — — 1 1088 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 CH OCH₃ 1 — — 0 1089 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 C —C₂H₄— 1 — — 1 1090 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 C —C₂H₄— 1 — — 2 1091 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 C —C₄H₈— 1 — — 1 1092 —C(CH₃)═CHCH═C(CH₃)— NR³ H 2 Si CH₃ 2 — — 0 1093 —C(CH₃)═CHCH═C(CH₃)— NR³ H 0 S(O)_(r) — 0 — 0 1 1094 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 S(O)_(r) — 0 — 0 0 1095 —C(CH₃)═CHCH═C(CH₃)— NR³ H 0 S(O)_(r) — 0 — 2 1 1096 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 S(O)_(r) — 0 — 2 0 1097 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 N(═O)_(q) CH₃ 1 0 — 0 1098 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 N(═O)_(q) CH₃ 1 1 — 0 1099 —C(CH₃)═CHCH═C(CH₃)— NR³ H 0 C═O — 0 — — 0 1100 —C(CH₃)═CHCH═C(CH₃)— NR³ H 0 C═O — 0 — — 1 1101 —C(CH₃)═CHCH═C(CH₃)— NR³ H 1 C═O — 0 — — 0

where M/Q/R are C/C/CH₃, Y is Al, X is —(CH₂)_(m)—U(R⁵)_(p)—(CH₂)_(m) ¹—, where m is 1, U is C═O, and p and m¹ are 0. Cmpd. No. R¹ R² W R³ R⁴ 1102 —CH═CHCH═CH— O — 3-Cl, 4-OCH₃ 1103 —CH═CHCH═CH— O — 3,5-diCl₂, 4-OCH₃ 1104 —CH═CHCH═CH— O — 3-CH₃, 4-OCH₃ 1105 —CH═CHCH═CH— O — 3,5-di(CH₃)₂, 4-OCH₃ 1106 —CH═CHCH═CH— O — 3,5-diCl₂, 4-n-OC₄H₉ 1107 —CH═CHCH═CH— O — 3-CH₃, 4-n-OC₄H₉ 1108 —CH═CHCH═CH— O — 3,5-di(CH₃)₂, 4-n-OC₄H₉ 1109 —CH═CHCH═CH— NR³ H 3-Cl, 4-OCH₃ 1110 —CH═CHCH═CH— NR³ H 3,5-diCl₂, 4-OCH₃ 1111 —CH═CHCH═CH— NR³ H 3-CH₃, 4-OCH₃ 1112 —CH═CHCH═CH— NR³ H 3,5-di(CH₃)₂, 4-OCH₃ 1113 —CH═CHCH═CH— NR³ H 3,5-diCl₂, 4-n-OC₄H₉ 1114 —CH═CHCH═CH— NR³ H 3-CH₃, 4-n-OC₄H₉ 1115 —CH═CHCH═CH— NR³ H 3,5-di(CH₃)₂, 4-n-OC₄H₉

(I)

where Y is Al Cmpd No. M/Q/R R¹ R² W R³ X R⁴ t v Z R⁶ R⁷ R⁸ 1116 N/C/CH₃ — CH₃ NR³ H —CH₂C(CH₃)₂— 3-Cl, 1 1 —C(R⁷)═C(R⁸)— CH₃ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1117 N/C/CH₃ — CH₃ N═ — —CHC(CH₃)₂— 3-Cl, 1 1 -C(R⁷)═C(R⁸)— CH₃ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1118 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— —(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 1119 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1 1 —C(R⁷)═C(R⁸)— CH₃ H H trans 1120 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1121 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 1 1 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1122 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— cyclopentyl H H 1123 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂- 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— cyclopentyl H H 1124 C/C/CH₃ —C(F)═CHCH═CH— O — —CH2CHr 3,5Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1125 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1126 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1127 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1128 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1129 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1130 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1131 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1132 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1133 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1134 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1135 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1136 C/C/CH₃ —CH═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1137 C/C/CH₃ —CH═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1138 C/C/CH₃ —CH═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1139 C/C/CH₃ —CH═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1140 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1141 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1142 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1143 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1144 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1145 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1146 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1147 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1148 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1149 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1150 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C≡C— C₃H₇ — — 1151 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C≡C— C₂H₄Ph — — 1152 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1153 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1154 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3-Cl, 1 1 —C≡C— H — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1155 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3-(O)_(t)—(CH₂)_(v)—Z—R⁶, 0 0 —C≡C— H — — 4-n-OC₄H₉ 115 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3-(O)_(t)—(CH₂)_(v)—Z—R⁶, 0 0 —C≡C— Si(CH₃)₃ — — 4-n-OC₄H₉ 1157 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂O— 3-Cl, 0 0 —C≡C— CH₂OCH₃ — — 1158 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂O— 3-Cl, 0 0 —C≡C CH₂OCH₃ — — HCl salt 1159 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1160 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1161 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1162 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1163 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1164 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1165 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1166 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1167 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1168 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1169 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1170 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1171 C/C/CH₃ —CH═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, O 0 —C≡C-C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1172 C/C/CH₃ —CH═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1173 C/C/CH₃ —CH═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1174 C/C/CH₃ —CH═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1175 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-Cl₂, O 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1176 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1177 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1178 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1179 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1180 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1181 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1182 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1183 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1184 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1185 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— C₂H₅ H — 1186 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— CH(CH₃)₂ H — 1187 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3-Cl, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1188 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— C₂H₅ CH₃ — 1189 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1190 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1191 C/C/CH₃ —CH═CHCH═CH— O — —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— CH₂Ph H — 1192 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1193 C/C/CH₃ —C(F)═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1194 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO-C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1195 C/C/CH₃ —CH═C(F)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═N0- C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1196 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1197 C/C/CH₃ —C(F)═C(F)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1198 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1199 C/C/CH₃ —C(F)═CHC(F)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1200 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1201 C/C/CH₃ —CH═C(F)C(F)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1202 C/C/CH₃ —C(CH₃)═CHCH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1203 C/C/CH₃ —C(CH3)═CHCH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1204 C/C/CH₃ —CH═CHC(CH3)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1205 C/C/CH₃ —CH═CHC(CH3)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1206 C/C/CH₃ —CH═C(CH3)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1207 C/C/CH₃ —CH═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1208 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1209 C/C/CH₃ —CH═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1210 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1211 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1212 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1213 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1214 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1215 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1216 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1217 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— O — —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1218 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 4-(0)1-(CH2)~-Z-R6 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1219 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1220 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1221 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1222 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1223 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1224 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1225 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1226 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1227 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1228 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1229 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1230 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1231 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1232 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1233 C/C/CH₃ —CH═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1234 C/C/CH₃ —CH═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1235 C/C/CH₃ —CH═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1236 C/C/CH₃ —CH═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH2)2, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1237 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1238 C/C/CH₃ —CH═CHCH═C(CH₃)— -NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1239 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1240 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1241 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1242 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1243 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1244 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1245 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1246 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═C(R⁸)— C₃H₇ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1247 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C-C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1248 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1249 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1250 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1251 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1252 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1253 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1254 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1255 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1256 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1257 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1258 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1259 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1260 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1261 C/C/CH₃ —CH═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1262 C/C/CH₃ —CH═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1263 C/C/CH₃ —CH═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1264 C/C/CH₃ —CH═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1265 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1266 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1267 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1268 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1269 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1270 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1271 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1272 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1273 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1274 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C≡C— C₃H₇ — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1275 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— CH(CH₃)₂ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1276 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3-Cl, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1277 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1278 C/C/CH₃ —CH═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1279 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1280 C/C/CH₃ —C(F)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1281 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1282 C/C/CH₃ —CH═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1283 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1284 C/C/CH₃ —C(F)═C(F)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1285 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1286 C/C/CH₃ —C(F)═CHC(F)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1287 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1288 C/C/CH₃ —CH═C(F)C(F)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1289 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1290 C/C/CH₃ —C(CH₃)═CHCH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1291 C/C/CH₃ —CH═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1292 C/C/CH₃ —CH═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1293 C/C/CH₃ —CH═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1294 C/C/CH₃ —CH═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1295 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1296 C/C/CH₃ —CH═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1297 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1298 C/C/CH₃ —C(CH₃)═C(CH₃)CH═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1299 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1300 C/C/CH₃ —C(CH₃)═CHC(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1301 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1302 C/C/CH₃ —CH═C(CH₃)C(CH₃)═CH— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1303 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-Cl₂, 0 0 —C(R⁷)═NO— CH₃ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1304 C/C/CH₃ —C(CH₃)═CHCH═C(CH₃)— NR³ H —CH₂CH₂— 3,5-(CH₃)₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1305 C/C/CH₃ —CH═CHCH═CH— —N═ — —CHCH₂— 3-Cl, 1 1 —C(R⁷)═C(R⁸)— CH₃ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1306 C/C/CH₃ —CH═CHCH═CH— —N═ — —CHC(CH₃)₂— 3-Cl, 1 1 —C(R⁷)═C(R⁸)— CH₃ H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1307 C/C/CH₃ —CH═CHCH═CH— NR³ H —CHCH₂— 3-Cl, 1 2 —C(R⁷)═C(R⁸)— H H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1308 C/C/CH₃ —CH═CHCH═CH— NR³ H —CHCH₂— 3-Cl, 1 2 —OCH₂C(R⁷)═C(R⁸)— H H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1309 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 3-Cl, 1 2 —C(R⁷)═C(R⁸)— Cl H H 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1310 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 3-Cl, 1 2 —C≡C— H — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1311 C/C/CH₃ —CH═CHCH═CH— NR³ H —CHCH₂— 3-Cl, 0 2 —C(R⁷)═C(R⁸)— CH₃ H H trans 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1312 C/C/CH₃ —CH═CHCH═CH— NR³ H —CHCH₂— 3-Cl, 0 2 —C(R⁷)═C(R⁸)— CF₃ H H trans 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1313 C/C/CH₃ —CH═CHCH═CH— NR³ H —CHCH₂— 3-Cl, 0 2 —C(R⁷)═C(R⁸)— F H F 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1314 C/C═O/— —CH═CHCH═CH— NR³ H —CHCH₂— 3-Cl, 0 3 —C≡C— H — — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1315 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— CH₂CH₂Ph H — 1316 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 3,5-F₂, 0 0 —C(R⁷)═NO— C₃H₇ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1317 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 3,5-F₂, 0 0 —C(R⁷)═NO— CH₂Ph H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1318 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 3,5-F₂, 0 0 —C(R⁷)═NO— CH₂CH₂Ph H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 1319 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═C(R⁸)— CO₂CH₃ H H trans 1320 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C≡C— C(CH₃)₂Ph — — 1321 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C≡C— C(CH₃)₂pyrid-2-yl — — 1322 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 4-(O)_(t)—(CH₂)_(v)—Z—R⁶ 0 0 —C(R⁷)═NO— C₃H₇ H — 1323 C/C/CH₃ —CH═CHCH═CH— O — —CHCH₂— 3,5-F₂, 0 0 —C(R⁷)═NO— C₂H₅ H — 4-(O)_(t)—(CH₂)_(v)—Z—R⁶

(I)

where Y is a bond bridging X and R⁴ Cmpd No. M/Q/R R¹ R² W X R⁴ 1324 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1325 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂OCH₃ 1326 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂OC₂H₅ 1327 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₇H₁₅ 1328 C/C/H —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1329 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1330 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₈H₁₇ 1331 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₃H₇ 1332 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— ..CH₂CH₂C(CH₃)₂O-n-C₅H₁₁ 1333 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₁₃ 1334 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₁₀H₂₁ 1335 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂OC₉H₁₉ 1336 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂OCH₂C₆H₅ 1337 C/C/CH₃ —CH═CHCH═CH— CH₂ —C₆H₅-3-OC₆H₅ — 1338 C/C/CH₃ —CH═CHCH═CH— CH₂ -n-C₉H₂₁ — 1339 C/C/CH₃ —C(NO₂)═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂OC₂H₅ 1340 C/C/NHCH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1341 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂CH₂— —C₆H₃-3-Cl-4-OH 1342 C/C/Cl —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1343 C/C/Cl —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1344 C/C/H —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1345 C/C/CH₃ —CH═CHCH═CH— CH₂ —S—CHCH(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1346 C/C/CH₃ —CH═CHCH═CH— CH₂ —R—CHCH(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1347 C/C/CH₃ —CH═CHCH═CH— CH₂ —S—CHCH(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1348 C/C/CH₃ —CH═CHCH═CH— CH₂ —R—CHCH(CH₃)CH₂— —CH₂CH₂C(CH₃)₂0-n-C₄H₉ 1349 C/C/N(CH₃)₂ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1350 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-(CH₂)₃CF₃ 1351 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n- (CH₂)₂Si(CH₃)₃ 1352 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂— —C₆H₄-3-O-n-C₆H₉ 1353 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂— —C₆H₄-3-O-n-C₆H₁₃ 1354 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂— —C₆H₄-4-O-n-C₆H₉ 1355 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂OCH₃CH₂— —OCH₂CH(C₂H₅)C₆H₉ 1356 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)₂ — 1357 C/C/CH₃ —CH═CHCH═CH— CH₂ cis- CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1358 C/C/CH₃ —CH═CHCH═CH— CH₂ cis- CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1359 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂— —C₆H₅-4-C(CH₃)₃ 1360 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂— —C₆H₄-3-Cl-4-O-n-C₆H₉ 1361 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂— —C₆H₄-3-Cl-4-OH 1362 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH₂— —C₆H₄-3-Cl-4-O-n-C₆H₉ 1363 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CHOC(CH₃)₂ 1364 C/C/CF₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1365 C/C/CH₃ —CH═CHCH═CH— CH₂ —C₆H₅-2-CH₃-3-C₆H₅ — 1366 C/C/CH₃ —CH═CHCH═CH— CH₂ —C₆H₄-3-OC₆H₅ — 1367 C/C/OH —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1368 C/C/N-pyrrollidine —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1369 C/C/N(CH₃)CH(CH₃)₂ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1370 C/C/CH₃ —CH═CHCH═CH— C₆H₄ -3-O(CH₂)₂C(CH₃)₂O-n-C₄H₉ — 1371 C/C/CH₃ —CH═CHCH═CH— C₆H₄ -3-OCH₂CH═C(CH₃)₂ — 1372 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═CHC₆H₄4-C(CH₃)₄ — 1373 C/C/SCH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1374 C/C/C(CH₃)₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1375 C/C/2-C₅H₅N —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1376 C/C/CF₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1377 C/C/C(CH₃)₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1378 C/C/C₆H₅ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1379 C/C/SCH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1380 C/C/2-C₅H₅N —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1381 C/C/CF₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1382 C/C/SOCH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₆H₉ 1383 C/C/N(CH₃)₂ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1384 C/C/OCH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1385 C/C/OCH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1386 C/C/CH₂CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1387 C/C/CH(CH₃)₂ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH═C(CH₃)₂ 1388 C/C/CH(CH₃)₂ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1389 C/C/CH₂CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂O-n-C₄H₉ 1390 C/C/CH₃ —CH═CHCH═CH— CH₂ -1-C₆H₄-4-C(CH₃)₂O-n-C₆H₉ — 1391 C/C/CH₃ —CH═CHCH═CH— CH₂ —C₆H₄-4-CCCH₂O-n-C₄H₉ — 1392 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂CH(CH₃)(CH₂)₃CH(CH₃)₂ — 1393 C/C/CH₃ —CH═CHCH═CH— CH₂ —C₆H₄-4-C(CH₃)₄ — 1394 C/C/CH₃ —CH═CHCH═CH— CH₂ trans-CH═NO(CH₂)₂C(CH₃)₂OCH₃ — 1395 C/C/CH₃ —CH═CHCH═CH— CH₂ cis-CH═NO(CH₂)₂C(CH₃)₂OCH₃ — 1396 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂C₆H₄-4-C(CH₃)₄ — 1397 C/C/CH₃ —CH═CHCH═CH— CH₂ —C═ONHCH₂C₆H₄-4-C(CH₃)₃ — 1398 C/C/CH₃ —CH═CHCH═CH— CH₂ —C═ONHC₆H₄-4-C(CH₃)₃ — 1399 C/C/CH₃ —CH═CHCH═CH— CH₂ —C₆H₄-4-CCC(CH₃)₂O-n-C₆H₉ — 1400 C/C/CH₃ —CH═CHCH═CH— CH₂ —C═ONH(CH₂)₃O-n-C₂H₅ — 1401 C/C/CH₃ —CH═CHCH═CH— C₆H₄ -4-OCH2CH═C(CH₃)₂ — 1402 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂OCH₂CH₂O-n-C₄H₉ — 1403 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂(OCH₂CH₂)₂O-n-C₂H₅ — 1404 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH═C(CH₃)CH₂— —CH₂CH₂C(CH₃)₂Cl 1405 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂C₆H₄-3-Cl-4-O-n-C₄H₉ — 1406 C/C/CH₃ —CH═CHCH═CH— CH₂ —CH₂C₆H₄-3-Cl-4-OH —

Insecticidal testing was conducted on specific compounds of the present invention. Specifically, the compounds referenced below were evaluated on 7-10 day old cotton seedlings infested with cotton aphid (Aphis gossypii). At least 12 hours prior to the test, leaf cuttings containing about 50 adult aphids were placed on leaves of each of duplicate cotton seedlings for each rate of application of compound of formula (I). Solutions of the compounds of formula (I) were prepared for testing by serial dilution of a standard solution comprised of an appropriate amount of the test material in a water/acetone solvent, which contained a small amount of a surfactant. Rates of application of compounds of formula (I) may range from about 1000 parts per million (ppm), or more, to about 3 ppm, or less, in a rate series of, for example, 1000 ppm, 300 ppm, 100 ppm, 30 ppm, 10 ppm, and 3 ppm. The solutions containing each rate of application of compounds of formula (I) were then sprayed to run-off to both the upper and lower portions of the leaves of the aphid-infested cotton seedlings. Each test of foliar-applied compounds of formula (I) included appropriate standard insecticides of known insecticidal activity and blank treatments to aid in assessing the insecticidal activity of the compounds of formula (I). Upon completion of the spraying with compounds of formula (I), the cotton seedlings were maintained in a growth chamber for a period of 72 hours. After this time, the seedlings were examined for dead insects. Insects were classified as dead if they were off-color or brown and desiccated. Upon completion of the evaluation of the test, the percent mortality of the cotton aphid for each rate of application of compounds of formula (I) was determined by comparison of the total number of dead insects to the total number of insects in the test.

Insecticidal activity data at selected rates of application are provided in Table 2. The test compounds of formula (I) are identified by numbers that correspond to those in Table 1. TABLE 2 Insecticidal Activity of Certain Diazole and Triazole Derivatives In Tests Against Cotton Aphid Rate of Rate of Cmpd. Appln. Percent Cmpd. Appln. Percent No. (ppm) Mortality No. (ppm) Mortality 9 1000 100  124 1000 27 125 1000 16 126 1000 40 127 1000 84 128 1000 17 129 100 19 130 100  3 131 1000 54 132 1000 97 133 1000 99 135 1000  86¹ 136 1000 98 138 1000 50 139 1000  8 140 1000 17 142 100  7 143 100  5 144 1000  87¹ 145 1000  95¹ 147 1000  97¹ 148 100 19 151 100  5 152 1000 60 153 1000 22 154 1000 100  155 1000  7 163 1000  88¹ 165 1000 97 166 1000 93 167 1000 97 168 1000  95² 169 1000 98 170 1000 68 171 1000 61 172 1000 100  173 1000 85 174 1000 91 175 100 64 176 100 65 177 100 28 178 1000  7 179 1000 97 180 1000 82 181 1000 100  183 1000 97 184 300 100  185 1000 88 186 1000 95 187 1000 100  188 1000 98 189 1000 100  190 1000 98 191 1000 31 192 100  3 193 100 74 194 1000 90 195 100  7 198 100 48 199 1000  7 200 1000 10 201 1000 62 202 10 18 203 1000 99 204 1000 56 205 100  7 206 1000 18 207 1000 63 208 1000 98 209 100 22 210 1000 11 211 1000 99 212 1000 14 242 100  8 244 1000 98 245 1000 100  246 1000 100  249 100  97¹ 262 1000  6 263 100 90 265 100 31 266 1000 100  267 1000 100  268 1000 28 269 1000 100  271 1000 95 272 1000 71 273 1000 84 275 1000 97 276 1000 91 277 1000 40 278 1000 59 279 1000 100  283 100 37 284 100 51 285 1000 31 290 1000 54 294 1000 44 295 1000  86¹ 296 100 13 297 100 35 298 100  6 299 100  8 300 100 41 301 100  59¹ 302 100  84¹ 303 100  8 305 1000 96 306 1000  3 314 1000 100  315 1000 76 316 100  9 317 100 53 318 1000  6 320 100 99 321 1000 98 322 1000 98 323 100  96¹ 326 100  95¹ 329 100 93 330 100 82 343 1000 98 344 100 48 345 100  89¹ 384 1000 99 401 100 99 413 100 80 417 100  3 921 1000 13 116 1000  8 1117 1000  4 119 1000  98¹ 1150 100  96¹ 151 100  4 1154 1000  2 155 1000 96 1156 1000 49 185 100  96² 1186 100 67 187 100 36 1188 100 74 191 100  4 1306 100 92 1315 100 13 1322 100 88 1323 100 97 ¹Average of two tests. ²Average of three tests.

The compounds of formula (I) of the present invention were insecticidally active in the above foliar test against cotton aphid.

Over forty of the compounds of formula (I) that were tested exhibited percent mortality of cotton aphid of 80% or greater at a rate of application of 1000 ppm. Five of the compounds of formula (I) exhibited percent mortality of cotton aphid of 60% or greater at a rate of application of 100 ppm. Of these five, compounds 249 and 263 exhibited 97% and 90% mortality, respectively, of cotton aphid at a rate of application of 100 ppm.

While this invention has been described with an emphasis upon preferred embodiments, it will be obvious to those of ordinary skill in the art that variations of the preferred embodiments may be used and that it is intended that the invention may be practiced otherwise than as specifically described herein. Accordingly, this invention includes all modifications encompassed within the spirit and scope of the invention as defined by the following claims. 

1. A gas barrier laminated film comprising a base material, a vapor deposited film of an inorganic oxide provided on the base material, and a gas barrier coating film provided on the vapor deposited film, said base material on its side where the vapor deposited film is provided, has been subjected to pretreatment or primer coating treatment, and said gas barrier coating film has been formed by coating a gas barrier coating liquid onto the inorganic oxide film and then heating the coating.
 2. The gas barrier laminated film according to claim 1, wherein the vapor deposited film has been formed by chemical vapor deposition.
 3. The gas barrier laminated film according to claim 1, wherein the vapor deposited film has been formed by physical vapor deposition.
 4. The gas barrier laminated film according to claim 1, wherein the base material is formed of a biaxially stretched polyester resin film, a biaxially stretched polyamide resin film, or a biaxially stretched polyolefin resin film.
 5. The gas barrier laminated film according to claim 1, wherein the pretreatment for the base material is glow discharge treatment, plasma treatment, corona treatment, or microwave treatment.
 6. The gas barrier laminated film according to claim 5, wherein oxygen, argon, nitrogen, helium gas, or a mixed gas composed of two or more of them is used for the pretreatment.
 7. The gas barrier laminated film according to claim 1, wherein the primer coating treatment for the base material is carried out by coating a coating liquid comprising a polyester resin, an acrylic resin, a urethane resin, and an isocyanate curing agent onto the base material.
 8. The gas barrier laminated film according to claim 2, wherein the vapor deposited film formed by the chemical vapor deposition has a structure comprising two or more silicon oxide layers each formed by plasma chemical vapor deposition in such a manner that at least two film formation chambers are used and, for respective chambers, two or more mixed gas compositions for film formation comprising at least: a monomer gas for film formation comprising one or more organosilicon compounds; an oxygen gas; and an inert gas, the two or more mixed gas compositions being different from each other in mixing ratio of the gas components, are used, and the each silicon oxide layer contains carbon atoms in its layer and the carbon content varies from layer to layer.
 9. The gas barrier laminated film according to claim 1, wherein the vapor deposited film on its side where the gas barrier coating film is formed, has been subjected to post treatment, and the post treatment is glow discharge treatment, plasma treatment, or microwave treatment.
 10. The gas barrier laminated film according to claim 1, wherein the gas barrier coating film is formed of a hydrolyzed condensate of an alkoxide or a hydrolysate of an alkoxide produced by polycondensing, by a sol-gel process, a composition comprising one or more alkoxides represented by general formula R¹ _(n)M(OR²)_(m) wherein M represents a metal atom; R¹ and R² represent an organic group having 1 to 8 carbon atoms; n is an integer of 0 (zero) or more; m is an integer of 1 or more; and n+m represents the valence of M, a polyvinyl alcohol and/or ethylene/vinyl alcohol.
 11. The gas barrier laminated film according to claim 10, wherein the composition further comprises a silane coupling agent.
 12. The gas barrier laminated film according to claim 1, wherein the gas barrier coating film has a structure of a plurality of layers.
 13. The gas barrier laminated film according to claim 1, wherein a vapor deposited film of an inorganic oxide is further provided on the gas barrier coating film provided on the vapor deposited film, and the gas barrier coating film is provided on the vapor deposited film.
 14. A process for producing a gas barrier laminated film according to claim 1 comprising the steps of: providing a base material and subjecting one side of the base material to pretreatment or primer coating treatment, forming a vapor deposited film of an inorganic oxide on the treated surface of the base material, and coating a gas barrier coating liquid onto the vapor deposited film and heating the coating at 150 to 250° C. to form a gas barrier coating film.
 15. The process according to claim 14, wherein the vapor deposited film has been formed by chemical vapor deposition.
 16. The process according to claim 14, wherein the vapor deposited film has been formed by physical vapor deposition.
 17. The process according to claim 14, wherein the pretreatment for the base material is glow discharge treatment, plasma treatment, corona treatment, or microwave treatment.
 18. The process according to claim 17, wherein oxygen, argon, nitrogen, helium gas, or a mixed gas composed of two or more of them is used for the pretreatment.
 19. The process according to claim 14, wherein the primer coating treatment for the base material is carried out by coating a coating liquid comprising a polyester resin, an acrylic resin, a urethane resin, and an isocyanate curing agent onto the base material.
 20. The process according to claim 15, wherein the vapor deposited film formed by the chemical vapor deposition has a structure comprising two or more silicon oxide layers each formed by plasma chemical vapor deposition in such a manner that at least two film formation chambers are used and, for respective chamber's, two or more mixed gas compositions for film formation comprising at least: a monomer gas for film formation comprising one or more organosilicon compounds; an oxygen gas; and an inert gas, the two or more mixed gas compositions being different from each other in mixing ratio of the gas components, are used, and the each silicon oxide layer contains carbon atoms in its layer and the carbon content varies from layer to layer.
 21. The process according to claim 14, which further comprises post-treating the vapor deposited film on its side where the gas barrier coating film is formed and wherein the post treatment is glow discharge treatment, plasma treatment, or microwave treatment.
 22. The process according to claim 21, which comprises the steps of coating the gas barrier coating liquid onto the vapor deposited film and heating the coating at 150 to 200° C.
 23. A laminated material for packaging, comprising a gas barrier laminated film according to claim 1, characterized in that a heat sealing resin layer is provided on the gas barrier coating film in the laminated film.
 24. The laminated material for packaging according to claim 23, wherein the gas barrier coating film and the heat sealing resin layer are laminated onto each other by melt extrusion through a primer layer and a melt extruded resin layer.
 25. The laminated material for packaging according to claim 23, wherein the heat sealing resin layer is formed of a polyolefin resin.
 26. The laminated material for packaging according to claim 23, wherein an intermediate base material is provided between the gas barrier coating film and the heat sealing resin layer.
 27. A packaging bag using a laminated material for packaging according to claim 23, the packaging bag comprising two laminated materials for packaging superimposed onto each other so that the heat sealing resin layer side of one of the laminated materials for packaging faces the heat sealing resin layer side of the other laminated material for packaging, the end part of the assembly having been heat sealed. 